Formulation and Evaluation of Optimized Natural Detoxifying Agents effervescent granuels into Gastro-retentive tablet

Abstract

Turmeric extract, garlic extract, and ginger extract have been traditionally used for their medicinal properties, and their combination may offer a synergistic effect in promoting health and well-being. Turmeric extract, rich in curcumin, has potent antioxidant and anti-inflammatory properties, which may help in reducing inflammation and oxidative stress. The research paper focused on Formulation and Evaluation of Optimized Natural Detoxifying Agents effervescent granuels into Gastro-retentive tablet containing a combination of turmeric extract, garlic extract, and ginger extract as natural detoxifying agents. The primary objective was to develop a novel, sustained-release formulation that leverages the synergistic potential of these herbal extracts to provide prolonged gastric residence time and improved detoxification efficacy. The formulation was optimized using various excipients and techniques, and it’s in vitro performance was evaluated through comprehensive studies, including floating behavior, release kinetics, and stability assessments. The results demonstrated that the formulated tablets exhibited excellent floating properties, sustained release, and good stability.The In vitro Buoyancy Studies of the gastroretentive tablet formulations reveals that Batch- 6 exhibits the most promising characteristics. With a floating lag time of 15 seconds, this formulation rapidly floats on the gastric fluid, ensuring quick onset of action. Moreover, it demonstrates a prolonged floating time of 12 hours, which would enable sustained release of the drug and improve patient compliance. Additionally, Batch-6 achieves a high drug release of 92%, indicating efficient delivery of the active ingredient. Overall, the optimized formulation of Batch-6 showcases excellent gastroretentive properties.