Role of Polysaccharides isolated from Nepeata septemcrenata in diabetic albino rats

  • Sawsan Ahmed Nasr1, Amel Abd El-Moneim Saad2, Mai Selmy khadar3 1Physiology Department, 2Biochemistry Department, and 3 Botany Department National Organization for Drug Control and Research (NODCAR)

Abstract

The present study was designed to investigate the antidiabetic activity of polysaccharide extracted from Nepeta septemcrenata (N.  septemcrenata). Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) (30 mg/kg b.w.). Twenty four adult male albino rats were divided into control group, diabetic group, diabetic group treated with gliclazide as a reference drug (10mg/kgb.w.) and diabetic group treated with polysaccharide extracted from N.  septemcernata (50mg/kg b.w). The experiment was lasted for 21 days.  STZ was significantly increased blood glucose, Alanin aminotransferase (ALT), Asparate aminotransferase (AST), alkaline phosphatase (ALP), total cholesterol, triglyceride  and  amylase associated with significantly decrease of total protein and albumin levels. Administration of polysaccharide extracted from N.  septemcrenata significantly attenuated glucose, α-amylase, ALT, AST, ALP, total protein, albumin, total cholesterol and triglyceride.  In Conclusion: The polysaccharide extracted from N.  septemcrenata display a significant antidiabetic properties in comparison with  gliclazide.

Keywords: Diabetes mellitus, Streptozotocin, Nepeta septemcrenata, Gliclazide, liver function.

Published
2017-10-30
How to Cite
Mai Selmy khadar3S. A. N. A. A. E.-M. S. (2017). Role of Polysaccharides isolated from Nepeata septemcrenata in diabetic albino rats. Journal of Biomedical and Pharmaceutical Research, 4(4). Retrieved from http://jbpr.in/index.php/jbpr/article/view/221
Issue
Vol. 4 No. 4 (2015)
Section
Research Articles

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