ESBL PRODUCING ENTEROBACTERIACEAE ISOLATES – PREVALANCE AND THEIR SUSCEPTIBILITY PATTERNS

  • V.N.Venkatesh1, Sudhindra.K.S2, avish K.M3, Shwetha.D.C4, T.K.S. Shetty5, Nirmala Grace.B5 1Professor and Head, Department of Microbiology, Basaveshwara Medical College & Hospital, Chitradurga, Karnataka, India 2Associate Professor, Department of Microbiology, Basaveshwara Medical College & Hospital, Chitradurga, Karnataka, India 3Assistant Professor, Department of Microbiology, Basaveshwara Medical College & Hospital, Chitradurga, Karnataka, India 4Assistant Professor, Department of Microbiology, Basaveshwara Medical College & Hospital, Chitradurga, Karnataka, India 5Assistant Professor, Department of Microbiology, Basaveshwara Medical College & Hospital, Chitradurga, Karnataka, India 6Assistant Professor, Department of Microbiology,Guntur Medical College, Guntur, Andhra Pradesh, India

Abstract

Background: Antimicrobial resistance seen among many Enterobacteriaceae isolates, especially those expressing extended spectrum beta lactamase (ESBL) enzymes are on the rise. This has limited our treatment options and made it very difficult to control these infections. Aim: To determine the prevalence of ESBL productions among Enterobacteriaceae isolates and also study their susceptibility patterns. Methods: A total of 220 clinical isolates of Enterobacteriaceae were screened for ESBL production by using five screening drugs.those resistant any one of the drugs were further tests for confirmation of ESBL production by Double disc synergy test (DDST). The ESBL producers were further studied for susceptibility patterns to other antibiotics.  Results: Among the 220 isolates 117 (53.17%) were found to ESBL producers. These ESBL producers were most sensitive to meropenem,  piperacillin/tazobactum and least sensitive to co-trimoxazole . Conclusions: The prevalence of multidrug resistant ESBL producers is very high and there is an urgent need to rationalize the use of antibiotics and minimize their mis-use.

Key words: Enterobacteriaceae, Extended spectrum beta lactamase, Double disc synergy test, Meropenem, Piperacillin/Tazobactum, Co-trimoxazole.

Published
2014-02-27
How to Cite
T.K.S. Shetty5, Nirmala Grace.B5V. S. avish K. S. (2014). ESBL PRODUCING ENTEROBACTERIACEAE ISOLATES – PREVALANCE AND THEIR SUSCEPTIBILITY PATTERNS. Journal of Biomedical and Pharmaceutical Research, 3(1). Retrieved from http://jbpr.in/index.php/jbpr/article/view/246
Issue
Vol. 3 No. 1 (2014)
Section
Research Articles

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