ANTIDIABETIC ACTIVITY OF 2-AMINO-(5-FLUORO-2-OXOINDOLIN-3-YLIDENE) BENZOXAZOLE-5-CARBOHYDRAZIDE IN RATS

  • Rama Narsimha Reddy Anreddy* Department of Pharmacology, Vaageswari College of Pharmacy, Karimanagar-505481, Telangana State, India

Abstract

The present study was designed to evaluate the antidiabetic activity of new indole derivatives i.e 2-Amino-(5-fluoro-2-oxoindolin-3-ylidene) benzoxazole-5-carbohydrazide against alloxan induced diabetic rats. Alloxan (120mg/kg) was used to induce diabetes in rats and the blood glucose levels were estimated by using commercial kit in the market. The test compound was administered to diabetic rats as single dose for one day at a dose of 50 & 100 mg/kg.  The compound produced a significant reduction (p<0.01) of blood glucose levels at a dose of 50 & 100mg/kg in diabetic rats in a dose dependant manner. 

Keywords: Diabetes mellitus, Antihyperglycemic, 2-Amino-(5-fluoro-2-oxoindolin-3-ylidene) benzoxazole-5-carbohydrazide, Alloxan.

Published
2014-12-30
How to Cite
Anreddy*, R. N. R. (2014). ANTIDIABETIC ACTIVITY OF 2-AMINO-(5-FLUORO-2-OXOINDOLIN-3-YLIDENE) BENZOXAZOLE-5-CARBOHYDRAZIDE IN RATS. Journal of Biomedical and Pharmaceutical Research, 3(6). Retrieved from http://jbpr.in/index.php/jbpr/article/view/322
Issue
Vol. 3 No. 6 (2014)
Section
Research Articles

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