IN VITRO ANTIOXIDANT ACTIVITY, TOTAL PHENOLIC CONTENTS AND PHYTOCHEMICAL EVALUATION FROM CRUDE EXTRACTS OF AN ENDANGERED PLANT CORDIA MACLEODII HOOK. F. THOMSON

  • Jagriti Chandrakar Laboratory of Molecular Taxonomy & Medicinal Plant Biology, Department of Botany, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India - 495009
  • Satish Dubey Laboratory of Molecular Taxonomy & Medicinal Plant Biology, Department of Botany, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India - 495009
  • Kundan Ojha Laboratory of Molecular Taxonomy & Medicinal Plant Biology, Department of Botany, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India - 495009
  • Rashmi Dehariya Laboratory of Molecular Taxonomy & Medicinal Plant Biology, Department of Botany, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India - 495009
  • Ashwini Kumar Dixit Laboratory of Molecular Taxonomy & Medicinal Plant Biology, Department of Botany, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India - 495009
DOI: https://doi.org/10.32553/jbpr.v8i3.620
Keywords: Cordia macleodii,, antioxidant, radical scavenging, phenolics, flavonoid, phytochemical.

Abstract

Cordia macleodii, an important medicinal plant traditionally used for the treatment of various disorders, including wound healing, jaundice, gastric ulcer, hepatoprotective activity and antivenom potential, thus the plant showed the high antioxidant properties. Successive extraction of leaf and barks powder with methanol and water was tested for quantitative determination of total phenolics, total flavonoids and various in vitro antioxidant activities. Phytochemical screening of crude plant extracts revealed the presence of sterols, alkaloid, flavonoid, phenolic, Reducing sugar, glycosides, tannins and saponins. All extracts showed the significant total phenolic and flavonoid contents and as well as radical scavenging and iron-chelating activities. Among all, methanol leaf extract was observed to be higher antioxidant activity than that of other extract. The methanol extracts showed greater antioxidant activity by DPPH scavenging the free radical with IC50 values of 7.63 ± 0.38 μg gm-1 along with scavenged free radical in a concentration depended manner, which is compare to the standard ascorbic acid.  Our results revealed that the presence of grater antioxidant activity of C. macleodii extract may be due to the high level of flavonoid and phenolic content in the plant. These results clearly indicated that C. macleodii is an effective natural antioxidant.

Key words: Cordia macleodii, antioxidant, radical scavenging, phenolics, flavonoid, phytochemical.

Published
2019-06-28
How to Cite
Chandrakar, J., Dubey, S., Ojha, K., Dehariya, R., & Dixit, A. K. (2019). IN VITRO ANTIOXIDANT ACTIVITY, TOTAL PHENOLIC CONTENTS AND PHYTOCHEMICAL EVALUATION FROM CRUDE EXTRACTS OF AN ENDANGERED PLANT CORDIA MACLEODII HOOK. F. THOMSON. Journal of Biomedical and Pharmaceutical Research, 8(3), 111-122. https://doi.org/10.32553/jbpr.v8i3.620
Issue
Vol. 8 No. 3 (2019)
Section
Research Articles

Creative Commons LicenseJournal of Biomedical and Pharmaceutical Research by Articles is licensed under a Creative Commons Attribution 4.0 International License.