MicroRNAs in health and disease; a review of its multifaceted roles

  • Manoj G Tyagi*, Gope Assudani+ Sowmya Vilvan*

Abstract

A new class of noncoding small RNAs, called microRNAs (miRNAs), has emerged as important regulators in biological processes. The important role of miRNAs in inflammation and immune response is highlighted by studies in which deregulation of miRNAs was demonstrated to accompany diseases associated with excessive inflammation. It is now known that miRNAs are involved in a broad range of developmental and physiological processes and their deregulation appears to play a fundamental role in the onset, progression, and dissemination of many cancers as well as in many other human diseases. This review article encompasses the roles of miRNAs that have been characterized in innate and adaptive immune responses. It also evaluates the roles of miRNAs as modulators of protein output from hundreds of target genes; they may impact physiological processes by regulating the concentrations of just a few key cellular proteins.

Key words: miRNA, protein, inflammation, immune, transcription

Author Biography

Manoj G Tyagi*, Gope Assudani+ Sowmya Vilvan*

*Department of Pharmacology*, Christian Medical College, Vellore 632002-

Indovax Laboratories+, Gurgaon, Haryana

Published
2016-02-28
How to Cite
Sowmya Vilvan*, M. G. T. G. A. (2016). MicroRNAs in health and disease; a review of its multifaceted roles. Journal of Biomedical and Pharmaceutical Research, 5(1). Retrieved from http://jbpr.in/index.php/jbpr/article/view/96
Section
Review Articles