Journal of Biomedical and Pharmaceutical Research http://jbpr.in/index.php/jbpr <p>&nbsp; &nbsp; &nbsp;<img src="/public/site/images/adminjbpr/nlm.jpg" width="219" height="144">&nbsp; &nbsp; &nbsp; &nbsp;<img src="/public/site/images/adminjbpr/www.jbpr_.in_.jpg">&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;<a title="http://www.icmje.org/journals-following-the-icmje-recommendations/" href="http://www.icmje.org/journals-following-the-icmje-recommendations/" target="_blank" rel="noopener"><img src="/public/site/images/adminjbpr/ICMJE_newsitem-e1514876485808.jpg" width="233" height="146"></a></p> <p>&nbsp;</p> <p>&nbsp; &nbsp; &nbsp;&nbsp;<a title="|| Pub-Med NLM ID (URL) ||" href="https://www.ncbi.nlm.nih.gov/nlmcatalog/101671502" target="_blank" rel="alternate noopener noreferrer">|| Pub-Med NLM ID (URL) ||</a>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;<a title="https://journals.indexcopernicus.com/search/reportList/40734" href="https://journals.indexcopernicus.com/search/reportList/40734" target="_blank" rel="noopener">|| Index Copernicus (URL) ||</a>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;<a title="http://www.icmje.org/journals-following-the-icmje-recommendations/#J" href="http://www.icmje.org/journals-following-the-icmje-recommendations/#J" target="_blank" rel="noopener">&nbsp;||<strong>ICMJE (URL)||</strong></a></p> <p>&nbsp; &nbsp; &nbsp; &nbsp;</p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;">Journal of Biomedical and Pharmaceutical Research (JBPR) is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Biomedical and Pharmaceutical Sciences.</span></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Medical || Dentistry || Biomedical Sciences&nbsp;|| Ayurveda&nbsp;|| Homeopathy&nbsp;||&nbsp;</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Anatomy, Physiology, Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology,&nbsp;Histopathology, Toxicology and all major disciplines of Biomedical Sciences.<br> <strong>Pharmaceutical Sciences || Allied Sciences&nbsp;</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Toxicology, Pharmaceutical and Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology and all major disciplines of Pharmaceutical&nbsp; Sciences.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Top Reasons for publication with us</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Quick Quality Review:</strong> The journal has strong international team of editors and reviewers, Rapid Decision and Publication</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Very Low Publication Fees:</strong> Comparable journals charge a huge sum for each accepted manuscript. JPBR only charge the fees necessary to recoup cost associated with running the journal</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Other features:</strong> DIDS Assigned and Implemented the Open Review System (ORS).</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Important Notice:</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Author can now directly send their manuscript as an email attachment to</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Innovative Library</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>editor@jbpr.in</strong>, <strong>drpriyankagupta6@gmail.com</strong></span></span></p> <p>&nbsp;</p> Innovative Library en-US Journal of Biomedical and Pharmaceutical Research 2589-8752 <p><a href="http://creativecommons.org/licenses/by/4.0/" rel="license"><img style="border-width: 0;" src="http://i.creativecommons.org/l/by/4.0/88x31.png" alt="Creative Commons License" width="60" height="21" border="0"></a><span style="line-height: 1.3em;">Journal of Biomedical and Pharmaceutical Research&nbsp;</span><span style="line-height: 1.3em;">by </span><span style="line-height: 1.3em;">Articles</span><span style="line-height: 1.3em;"> is licensed under a </span><a style="line-height: 1.3em;" title="Journal of Biomedical and Pharmaceutical Research" href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="license noopener">Creative Commons Attribution 4.0 International License</a><span style="line-height: 1.3em;">.</span></p> COMPARATIVE STUDY ON ANTI-INFLAMMATORY SYNERGISTIC ACTIVITY OF LORNOXICAM USING TURMERIC OIL IN TDDS http://jbpr.in/index.php/jbpr/article/view/544 <p>The present research work was an attempt to develop, evaluate matrix-type transdermal therapeutic system containing lornoxicam with hydrophilic polymer (HPMC E-5) and turmeric oil (leaf extract) by the solvent evaporation technique. The turmeric oil has been used for two reasons, one is to see whether it act as natural penetration enhancer (replacing chemical enhancers) and also to compare the anti-inflammatory synergism between the drug and the oil itself. The anti-inflammatory activity of turmeric oil has been well documented. The physicochemical compatibility of the drug, polymers and oil was studied by infrared spectroscopy. The results suggested no physicochemical incompatibility between them. Five&nbsp; transdermal patch formulations (F1 to F5) consists of HPMC E5 (300 mg fixed) and turmeric oil in the concentrations 3%, 4%, 5%, 6% and 7% respectively were prepared. All formulations carried 10% w/v of Polyethylene glycol as plasticizer in dichloromethane and methanol (4:1) as solvent system. The prepared transdermal patches were evaluated for in vitro release, moisture absorption, moisture loss and mechanical properties. The diffusion studies were performed by using modified Franz diffusion cells. The formulation, F3 showed maximum release 97.56% as compared to patch without any penetration enhancer (58.83%).The synergistic activity has been determined by Carrageenan induced rat paw edema test and the results have confirmed the synergistic activity between the drug and turmeric oil. The developed transdermal patches may increase the efficacy of lornoxicam for the therapy of arthritis and other painful muscular conditions.</p> <p><strong>Keywords: Transdermal system, HPMC, Turmeric oil, penetration enhancer, Synergistic activity.</strong></p> Wasim Ahmed Dipti Srivastava Himani Awasthi Bankim Chandra Nandy ##submission.copyrightStatement## 2018-07-28 2018-07-28 7 4 IMPLEMENTATION AND ASSESSMENT OF STUDENTS’ PERCEPTION ON EFFECTIVENESS OF KAHOOT GAME-BASED EDUCATIONAL TOOL IN LEARNING MICROBIOLOGY http://jbpr.in/index.php/jbpr/article/view/542 <p><strong>Introduction: </strong>Game-based learning exercises are highly effective in promoting students learning compared to conventional didactic lectures. Kahoot is one of the e-learning tools highly appreciated by many educators and found that its incorporation in classroom lectures promotes students’ learning process and motivates them to learn better. Also, it provides an opportunity for students to correct their mistakes in the subject matters and thereby enhance their knowledge and improve their examination performance. The present study was undertaken to assess the students’ perception about the usefulness of Kahoot e-learning tool in Medical education.</p> <p><strong>Methodology:</strong> A cross-sectional study was conducted among 5th-year medical students at Oman Medical College during the academic session 2017-18. The study was intended to assess the perception of students regarding usefulness and effectiveness of Kahoot online tool in learning Microbiology and Immunology. The students’ perception on Kahoot was assessed through 5 points Likert Scale questionnaire. The data were collected and statistically analyzed using SPSS 22.</p> <p><strong>Results: </strong>A total of 110 fifth year medical students voluntarily participated in the study. Majority of the students (≈88%) perceived Kahoot as a very effective and fun-filled learning tool. Students also highly rated the activity in terms of effectiveness in motivation, correcting mistakes, knowledge retention, and improving exam grades.</p> <p><strong>Conclusion: </strong>Kahoot is an excellent e-learning tool that is feasible and practical to use for promoting and encouraging students to learn better. It provides a positive environment in the classroom, improves their concentration and knowledge retention. It motivates the students to learn in a fun-filled, enjoyable, and friendly competitive environment.&nbsp; It is also a good game based e-learning tool for formative assessment.</p> <p><strong><u>Keywords</u></strong><strong>: </strong>Assessment, e-learning<strong>, </strong>Immunology<strong>, </strong>Kahoot, Microbiology</p> Mohan B S Vinod Nambiar Rajeev Arvindakshan ##submission.copyrightStatement## 2018-08-03 2018-08-03 7 4 EVALUATION OF QUALITY OF LIFE IN HEMODIALYSIS PATIENTS AND MEASUREMENT OF CLINICAL OUTCOMES http://jbpr.in/index.php/jbpr/article/view/541 <p>End stage renal disease is the final stage of chronic kidney disease in which the kidneys longer function well enough to meet needs of life. The treatments for ESRD are dialysis or kidney transplant. Hemodialysis (HD) is the most common type of dialysis which can cause significant impairment in health related quality of life (HRQOL) and outcomes. The aim of the present study was to learn about the quality of life in patients receiving dialysis treatment and to evaluate the influence of various factors associated with poor HRQOL. In addition, this study compares SF-36 scores of various domains between survival and deceased patients. The study was a prospective observational, analytical study, conducted for 7 months in IPD/OPD of Dialysis Department at Sagar Hospitals, Bengaluru. The validated and authorized health related quality of life questionnaire (RAND SF-36) consists of 36 questions measuring physical and mental health status was used. Statistical significance of differences in physical component summary and mental component summary was calculated by using Kruskal-Wallis test and the Mann-Whitney<em> U</em> test. A total of 126 patients meeting the study criteria participated and completed the study. Overall, 85(67%) were male and the mean ± standard deviation age was 58.10± 11.38 years. Both PCS and MCS scores have significant negative association with age, total number of chronic medications and the total number of chronic co-morbid diseases. Among eight scales of SF-36, Bodily Pain (BP), Physical Function (PF), Role limitation due to Physical health (RP) and Vitality scores were significantly higher in surviving patients when compared to that of deceased patients respectively. Our study showed that important variables like PF, BP, RP and VT scores can be taken into consideration when dealing with hemodialysis patients. Healthcare providers should be aware of poor physical health as well as mental health among female gender, elderly patients, unemployed patients, patients with no formal education, multiple co-morbid diseases, and multiple chronic medications to improve their quality of life.&nbsp;</p> Rama Krishna Prudhivi Shaik Ayesha Promod Giri Anuradha . ##submission.copyrightStatement## 2018-08-03 2018-08-03 7 4 A COMPARATIVE STUDY FOR THE ASSESSMENT OF COMPLIANCE IN ALCOHOLICS AND NON-ALCOHOLIC PATIENTS ON ANTI-TUBERCULAR THERAPY – A PROSPECTIVE OBSERVATIONAL STUDY http://jbpr.in/index.php/jbpr/article/view/543 <p><strong>ABSTRACT</strong></p> <p><strong>Background: </strong>Compliance to Anti-tubercular therapy is very important for the treatment and also to prevent the relapse or failure of the treatment. Nevertheless, many people fail to adhere to the therapy and various factors plays a role in the process. This study was undertaken to assess the adherence in alcoholics and non-alcoholic patients on Anti-tubercular therapy and to evaluate the factors affecting the compliance towards the therapy. <strong>Materials and Methods: </strong>It was a questionnaire based observational study where 100 patients (50 alcoholics and 50 non-alcoholics) receiving anti-tubercular therapy were interviewed using Morisky Medication Adherence Scale 4 and self-designed questionnaires. <strong>Results: </strong>In our study highest adherence was found in non-alcoholics compared to alcoholics. Level of adherence were High (14), Medium (30) and Low (6) in non-alcoholics whereas High (6), Medium (28) and Low (16) in alcoholics receiving anti-tubercular therapy. Reasons for non-adherence were described as Forgetfulness 3 %, Vomiting 2 %, travelling to other places 12 %, work 11%, far distance 5%, other reasons 3% by non-alcoholics as compared to 11%, 8%, 9%, 7%, 4% and 3% respectively by alcoholics. <strong>Conclusion: </strong>Our findings suggests that the adherence towards the anti-tubercular therapy were high in non-alcoholics as compared to alcoholics. So, the habit of consumption of alcohol is affecting the adherence towards the therapy.</p> <p>Keywords: Adherence, Anti-tubercular therapy, Morisky medication adherence scale</p> Shetty Rashmitha kumari Anil Pandit, Doctor of Pharmacy C. Suhash Reddy K K Shyamala, Department Of TB and Pulmonary Medicine ##submission.copyrightStatement## 2018-08-04 2018-08-04 7 4 A COMPARATIVE STUDY FOR THE ASSESSMENT OF KNOWLEDGE AND QUALITY OF LIFE IN ALCOHOLICS AND NON-ALCOHOLIC PATIENTS RECEIVING ANTI-TUBERCULAR THERAPY – A PROSPECTIVE OBSERVATIONAL STUDY http://jbpr.in/index.php/jbpr/article/view/545 <p><strong>Background: </strong>&nbsp;Tuberculosis is a global threat and has a very high prevalence every year. Knowledge regarding the tuberculosis is very significant for the detection, prevention and treatment at appropriate time and also to alleviate the quality of life of the patient. This study was undertaken to assess the knowledge and quality of life of the patients receiving anti-tubercular therapy. <strong>Materials and Methods: </strong>It was an observational study where 100 patients (50 alcoholics and 50 non-alcoholics) included in the study were asked a framed questionnaire to assess their knowledge regarding tuberculosis and quality of life. <strong>Results: </strong>Out of 100 patients the highest reported answer among alcoholics was cough (37) as compared to non-alcoholics cough (45). Both alcoholics (35) and non-alcoholics (32) reported air droplets as the prominent mode of acquiring of Tuberculosis, whereas covering mouth and nose (28) and good nutrition (44) were reported as the most known parameter for the prevention of Tuberculosis by alcoholics and non-alcoholics respectively. The Quality of life of non-alcoholics patient were found better as compared to alcoholics. <strong>Conclusion: </strong>Our findings suggests that the quality of life of the alcoholic people is affected and is comparatively lower as compared to non-alcoholics and also the alcoholics possessed minimal knowledge regarding the disease.</p> <p>Keywords: Quality of life, knowledge assessment, Anti-tubercular therapy</p> Anil Pandit Shetty Rashmitha Kumari K. K. Shyamala C. Suhash Reddy ##submission.copyrightStatement## 2018-08-08 2018-08-08 7 4 SELF-MEDICATION AND ROLE OF PHARMACIST IN PATIENT EDUCATION http://jbpr.in/index.php/jbpr/article/view/547 <p><strong>Introduction: </strong>Pharmacy is the art, science and practice of preparing, preserving, compounding and dispensing of drugs and it also includes modern services related to health care including clinical services, reviewing medications for safety and efficacy, and providing drug information. The pharmacy services provided in India seem to be mainly product-sale focused and traditionally practiced with very minimum or negligible focus on the trending or modern clinical services such as patient education on prescribed medication and also over the counter medications which may be taken by the patient. Therefore, strategies are to be implemented and health system reforms need to be introduced to follow the trending clinical services in order to improve the quality of pharmacy services with the main aim of optimizing the patient care.</p> <p><strong>Objective: </strong>Assess self-medication and role of pharmacist in patient education in the Department of Pharmacy, Dr. B.R. Ambedkar Medical College and Hospital, Bengaluru.</p> <p><strong>Methodology: </strong>This was a Hospital based observational study, in which data collection was carried out over a period of 6 months from the outpatient pharmacy. Data was collected after obtaining consent from the patients. A self-designed questionnaire for assessing knowledge on self-medication and patient satisfaction were used for data collection. Then follow-up was made to assess improvement in medication adherence. The data collected was then analyzed using suitable statistical methods.</p> <p><strong>Result: </strong>A total of 250 patients were enrolled from the patients visiting out-patient pharmacy. Out of which, 60.8% were females and 39.2% were males. Among both genders females (60.80%) showed more interest in participating in our study. The mean age of the study subjects was found to be 37.86±17.99 years. In our study which involved 250 patients, 42% (n=105) were found to be on self-medication. Out of 42%, 17.20% (n=43) were males and 24.80% (n=62) were females. The age group ranging between 40-59years, 34.29% (n=36) were on high in number compared other age groups out of which 22.85% (n=24) were females and 11.44% (n=12) were males. Overall satisfaction was calculated using Likert scale, and the overall mean patient satisfaction score was found to be</p> <p>4.56±0.55 (a score of 5 indicated most satisfied and 1 indicated least satisfied).</p> <p><strong>Conclusion: </strong>The project aims to demonstrate the role of pharmacists in improving the patient health care and motivating the pharmacists not to limit the pharmacy profession to just dispensing. It is quite necessary to impart this knowledge to every pharmacy in India where it is practiced traditionally with only dispensing as their main role and not extending further to better services like self-medication assessment and Improve medication adherence.</p> <p><strong>Keywords: Hospital, pharmacy, hospital ambulatory, pharmacist, adherence, patient, satisfaction, medication, self medication.</strong></p> Leila Esfandiari Shaik MD Rafi Ashma Nepal Kanann Gopal ##submission.copyrightStatement## 2018-08-13 2018-08-13 7 4