Journal of Biomedical and Pharmaceutical Research http://jbpr.in/index.php/jbpr <p>&nbsp; &nbsp; &nbsp;<img src="/public/site/images/adminjbpr/nlm.jpg" width="219" height="144">&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;<a title="http://www.icmje.org/journals-following-the-icmje-recommendations/" href="http://www.icmje.org/journals-following-the-icmje-recommendations/" target="_blank" rel="noopener"><img src="/public/site/images/adminjbpr/ICMJE_newsitem-e1514876485808.jpg" width="233" height="146"></a></p> <p>&nbsp;</p> <p>&nbsp; &nbsp; &nbsp;&nbsp;<a title="|| Pub-Med NLM ID (URL) ||" href="https://www.ncbi.nlm.nih.gov/nlmcatalog/101671502" target="_blank" rel="alternate noopener noreferrer">|| Pub-Med NLM ID (URL) ||</a>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;<a title="http://www.icmje.org/journals-following-the-icmje-recommendations/#J" href="http://www.icmje.org/journals-following-the-icmje-recommendations/#J" target="_blank" rel="noopener">&nbsp;||<strong>ICMJE (URL)||</strong></a></p> <p>&nbsp; &nbsp; &nbsp; &nbsp;</p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;">Journal of Biomedical and Pharmaceutical Research (JBPR) is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Biomedical and Pharmaceutical Sciences.</span></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Medical || Dentistry || Biomedical Sciences&nbsp;|| Ayurveda&nbsp;|| Homeopathy&nbsp;||&nbsp;</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Anatomy, Physiology, Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology,&nbsp;Histopathology, Toxicology and all major disciplines of Biomedical Sciences.<br> <strong>Pharmaceutical Sciences || Allied Sciences&nbsp;</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Toxicology, Pharmaceutical and Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology and all major disciplines of Pharmaceutical&nbsp; Sciences.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Top Reasons for publication with us</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Quick Quality Review:</strong> The journal has strong international team of editors and reviewers, Rapid Decision and Publication</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Very Low Publication Fees:</strong> Comparable journals charge a huge sum for each accepted manuscript. JPBR only charge the fees necessary to recoup cost associated with running the journal</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Other features:</strong> DIDS Assigned and Implemented the Open Review System (ORS).</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Important Notice:</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Author can now directly send their manuscript as an email attachment to</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Innovative Library</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>editor@jbpr.in</strong>, <strong>drpriyankagupta6@gmail.com</strong></span></span></p> <p>&nbsp;</p> en-US <p><a href="http://creativecommons.org/licenses/by/4.0/" rel="license"><img style="border-width: 0;" src="http://i.creativecommons.org/l/by/4.0/88x31.png" alt="Creative Commons License" width="60" height="21" border="0"></a><span style="line-height: 1.3em;">Journal of Biomedical and Pharmaceutical Research&nbsp;</span><span style="line-height: 1.3em;">by </span><span style="line-height: 1.3em;">Articles</span><span style="line-height: 1.3em;"> is licensed under a </span><a style="line-height: 1.3em;" title="Journal of Biomedical and Pharmaceutical Research" href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="license noopener">Creative Commons Attribution 4.0 International License</a><span style="line-height: 1.3em;">.</span></p> editor@jbpr.in (Innovative Library) drpriyankagupta6@gmail.com (A Gupta) Wed, 27 Mar 2019 07:23:13 +0000 OJS 3.1.0.1 http://blogs.law.harvard.edu/tech/rss 60 METHYLATION OF PROLACTIN AND OXYTOCIN HORMONE GENES; PHYSIOLOGICAL FUNCTIONS AND ROLES IN DISEASE STATES http://jbpr.in/index.php/jbpr/article/view/584 <p>DNA methylation is the key mechanism in epigenetic events involved in gene silencing and gene genome stability. The two important hormones involved in social behaviour, lactation and parturition are Oxytocin and Prolactin. There is growing interest in epigenetic modification of oxytocin and prolactin in neurotransmission interaction and their functional significance. This review outlines the influence of DNA methylation of genes of oxytocin and prolactin hormones/receptors and impact on their biological roles and influence on endocrine function in mammals.</p> <p><strong>Keywords:</strong> Prolactin, Oxytocin, receptor, DNA methylation, epigenetics</p> Manoj G Tyagi, Deepak G Shewade, Megha Chaudhary, Mohammed I Wani, Shyam S Yadav ##submission.copyrightStatement## http://jbpr.in/index.php/jbpr/article/view/584 Wed, 27 Mar 2019 07:22:32 +0000 ANALYSIS OF COST VARIATION OF ANTI-CANCER DRUGS http://jbpr.in/index.php/jbpr/article/view/582 <p><strong>Introduction:</strong> Indian pharmaceutical industry being one of the largest pharmaceutical markets in the world has a large number of branded formulations and generic brands of the same drug with a large difference in their selling price. The study was planned to find out variation in cost of&nbsp; anti-cancer drugs</p> <p><strong>Methods:</strong> Information was sourced from NETMED MOBILE APP. The drug formulation being manufactured by only one company or being manufactured by different companies; however, in different strengths would be excluded. Difference in the maximum and minimum price of the same drug formulation manufactured by different pharmaceutical companies and percentage variation in price would be calculated.</p> <p><strong>Results:</strong> The maximum cost variation in the alkylating agents group was seen with Oxaliplatin 50mg/10ml (71.43%). In the antimetabolite group the maximum cost variation was seen in Gemicitabine 1000mg (357.67%). 68.7% cost variation was observed with Paclitaxel 30mg/5ml in the antimitotic natural products group. Doxorubicin 10mg/5ml showed the maximum cost variation in the cytotoxic antibiotic group as well amongst all the anticancer drugs. Within the targeted group imatinib 400mg showed the maximum cost variation i.e 505.20%.</p> <p><strong>Conclusion:</strong> Thus, this study highlights that there is a significant price difference among the anti-cancer drugs manufactured by different companies. Hence stringent measures should be brought into implementation by the government and concerned agencies for uniformity in drug pricing.</p> Prasan R. Bhandari ##submission.copyrightStatement## http://jbpr.in/index.php/jbpr/article/view/582 Sat, 30 Mar 2019 06:00:31 +0000 ROLE OF PHARMACIST INTERVENTION ON COPD PATIENTS OF SELECTED AREAS IN CHITRADURGA: A KAP STUDY http://jbpr.in/index.php/jbpr/article/view/586 <p><strong>Background:</strong> Chronic obstructive pulmonary disease (COPD) is preventable and treatable disease state characterized by air flow limitation that is not fully reversible. Severity of the symptoms is increased during exacerbations.</p> <p><strong>Objectives:</strong> The purpose of the study is to assess and improve the knowledge regarding COPD among study subjects.</p> <p><strong>Materials and Methods:</strong> A Cross-sectional interventional study was carried out among the peoples in selected areas of the Chitradurga city for a period of six months.</p> <p><strong><em>Result: </em></strong>A total 207 subjects enrolled in the study in that 155 male and 52 females. In our study mean score of post test was more (5.87±1.68) when compare to pre-test (2.63±1.46) which show significant increase in their knowledge after educating them (p=0.000). A total of 207 subjects were enrolled into the study. SPSS Software was used to calculate the statistical estimation. Paired t-test was used to detect the association status of different variables.</p> <p><strong>Conclusion:</strong> The relatively good level of COPD awareness needs to be maintained to facilitate future prevention and control of the disease. This study had identified that negative illness perceptions should be targeted, so that they will not avoid patients from seeking for COPD treatment and adhere to it.</p> <p><strong>Key words:</strong> Cross sectional study, Knowledge, practice, COPD.</p> Melvin K Mathews, Abubaker Siddiq, Bharathi D R ##submission.copyrightStatement## http://jbpr.in/index.php/jbpr/article/view/586 Wed, 03 Apr 2019 04:32:56 +0000 UTILISATION STUDY OF ORAL HYPOGLYCAEMIC MEDICINES AT A TERTIARY CARE HOSPITAL http://jbpr.in/index.php/jbpr/article/view/585 <p>Drug utilization research establishes the current trend in the use of antidiabetic drugs including the new drug and to identify irrational prescription. India has a sizeable Diabetic Population with more than 72 million type-2 diabetic patients. Glycemic control remains the major goal for prevention of complications arising from diabetes. Poor glycemic control can be prevented by using rational &amp; safe use of anti-diabetic drugs. A prospective observational study was carried out for a period of three years with the aim to study drug utilization evaluation of Oral Hypoglycaemic Medicines. A total of 468 patients were enrolled with the inclusion criteria of patients with past history of diabetes as well as newly diagnosed cases. The study showed that diabetes is more prevalent in females than males and also found a higher prevalence of the disease among elderly patients. The study revealed the use of Metformin as the most commonly utilized drug among diabetic population. Glimeperide and Metformin were the most commonly prescribed anti-diabetic combination. The results of this study provide real-life data, which will help to formulate newer strategies to improve delivery of diabetes care.</p> <p><strong>Key words: </strong>Diabetes, Drug Utilisation, Prospective, Prevalence</p> Abubaker Siddiq, Bharathi DR ##submission.copyrightStatement## http://jbpr.in/index.php/jbpr/article/view/585 Fri, 05 Apr 2019 06:02:37 +0000 THE DEVELOPMENT AND APPLICATION OF TONGUE DIAGNOSIS CABIN http://jbpr.in/index.php/jbpr/article/view/587 <p>On the basis of a large number of previous studies, we develop the TCM Tongue diagnosis mobile phone software based on artificial intelligence technology which is named Tongue Diagnosis Cabin. The software utilizes and improves the digital objectification technology of modern tongue image to overcome the influence of the pixel limitation of the mobile phone, the complex shooting environment, the unstable light source and other conditions on the color and definition of the original tongue image, and reduces the total difference between the remote tongue image and the original tongue image color, so as to achieve clinical visual equivalence. The software is based on the mobile phone, which is easy to operate with intelligently guidance and superior performance, and can promote the development of digitalization and telemedicine of tongue diagnosis.</p> <p><strong>Keywords</strong>: tongue diagnosis cabin; tongue diagnosis; intelligence; mobile; telemedicine</p> Yu- Hui Ma, Lin- Feng Li, Yu- Xuan Zhang, Yu Zhang, Yu- Ting Wang, Si- Yuan Han, Yu- Rong Liang ##submission.copyrightStatement## http://jbpr.in/index.php/jbpr/article/view/587 Thu, 18 Apr 2019 15:41:33 +0000