Journal of Biomedical and Pharmaceutical Research http://jbpr.in/index.php/jbpr <p>&nbsp; &nbsp; &nbsp;<img src="/public/site/images/adminjbpr/nlm.jpg" width="219" height="144">&nbsp; &nbsp; &nbsp; &nbsp;<img src="/public/site/images/adminjbpr/www.jbpr_.in_.jpg">&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;<a title="http://www.icmje.org/journals-following-the-icmje-recommendations/" href="http://www.icmje.org/journals-following-the-icmje-recommendations/" target="_blank" rel="noopener"><img src="/public/site/images/adminjbpr/ICMJE_newsitem-e1514876485808.jpg" width="233" height="146"></a></p> <p>&nbsp;</p> <p>&nbsp; &nbsp; &nbsp;&nbsp;<a title="|| Pub-Med NLM ID (URL) ||" href="https://www.ncbi.nlm.nih.gov/nlmcatalog/101671502" target="_blank" rel="alternate noopener noreferrer">|| Pub-Med NLM ID (URL) ||</a>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <a title="https://journals.indexcopernicus.com/search/details?id=40734&amp;lang=en" href="https://journals.indexcopernicus.com/search/details?id=40734&amp;lang=en" target="_blank" rel="noopener">&nbsp;&nbsp;|| Index Copernicus (URL) ||&nbsp;</a> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;<a title="http://www.icmje.org/journals-following-the-icmje-recommendations/#J" href="http://www.icmje.org/journals-following-the-icmje-recommendations/#J" target="_blank" rel="noopener">&nbsp;||<strong>ICMJE (URL)||</strong></a></p> <p>&nbsp; &nbsp; &nbsp; &nbsp;</p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;">Journal of Biomedical and Pharmaceutical Research (JBPR) is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Biomedical and Pharmaceutical Sciences.</span></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Medical || Dentistry || Biomedical Sciences&nbsp;|| Ayurveda&nbsp;|| Homeopathy&nbsp;||&nbsp;</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Anatomy, Physiology, Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology,&nbsp;Histopathology, Toxicology and all major disciplines of Biomedical Sciences.<br> <strong>Pharmaceutical Sciences || Allied Sciences&nbsp;</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Toxicology, Pharmaceutical and Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology and all major disciplines of Pharmaceutical&nbsp; Sciences.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Top Reasons for publication with us</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Quick Quality Review:</strong> The journal has strong international team of editors and reviewers, Rapid Decision and Publication</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Very Low Publication Fees:</strong> Comparable journals charge a huge sum for each accepted manuscript. JPBR only charge the fees necessary to recoup cost associated with running the journal</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Other features:</strong> DIDS Assigned and Implemented the Open Review System (ORS).</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Important Notice:</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Author can now directly send their manuscript as an email attachment to</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Innovative Library</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>editor@jbpr.in</strong>, <strong>drpriyankagupta6@gmail.com</strong></span></span></p> <p>&nbsp;</p> en-US <p><a href="http://creativecommons.org/licenses/by/4.0/" rel="license"><img style="border-width: 0;" src="http://i.creativecommons.org/l/by/4.0/88x31.png" alt="Creative Commons License" width="60" height="21" border="0"></a><span style="line-height: 1.3em;">Journal of Biomedical and Pharmaceutical Research&nbsp;</span><span style="line-height: 1.3em;">by </span><span style="line-height: 1.3em;">Articles</span><span style="line-height: 1.3em;"> is licensed under a </span><a style="line-height: 1.3em;" title="Journal of Biomedical and Pharmaceutical Research" href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="license noopener">Creative Commons Attribution 4.0 International License</a><span style="line-height: 1.3em;">.</span></p> editor@jbpr.in (Innovative Library) drpriyankagupta6@gmail.com (A Gupta) Fri, 16 Nov 2018 06:12:37 +0000 OJS 3.1.0.1 http://blogs.law.harvard.edu/tech/rss 60 FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF VALDECOXIB http://jbpr.in/index.php/jbpr/article/view/558 <p>Valdecoxib is a selective COX- II inhibitor with anti – inflammatory, analgesic and antipyretic properties. The poor aqueous solubility of the drug leads to variable dissolution rates. In the present study an attempt has been made to prepare fast dissolving tablets of Valdecoxib in the oral cavity with enhanced dissolution rate. The fast dissolving tablets of Valdecoxib was prepared with some carriers (polymers) and super disintegrants such as Polyvinyl Pyrrolidone (PVP), Sodium Carboxy Methyl Cellulose (SCMC), Crospovidone NF and β – Cyclodextrin. The above mentioned all carriers and superdisintegrants were taken in different proportions of 5, 10, and 15%. All the formulations of the fast dissolving tablets of Valdecoxib were prepared by direct compression technique. The blend was examined for Angle of repose, Bulk density, Compressibility index and Hausner’s ratio. The prepared tablets were evaluated for hardness, drug content uniformity, friability, disintegration time and dissolution rate. An effective pleasant testing formulation released 99.88% drug within 10 minutes. The prepared formulations drug release was found to be comparable with the marketed dispersible tablets.</p> <p><strong>Keywords: </strong>Fast dissolving tablets, Super-disintegrants, Valdecoxib, Crosspovidone, Sodium Carboxy Methyl Cellulose.</p> K Kareemuddin Ansari, Neeraj Sharma ##submission.copyrightStatement## http://jbpr.in/index.php/jbpr/article/view/558 Mon, 19 Nov 2018 00:00:00 +0000 DESIGN AND IN VITRO/IN VIVO EVALUATION OF EXTENDED RELEASE MATRIX TABLETS OF NATEGLINIDE http://jbpr.in/index.php/jbpr/article/view/559 <p><strong>Aim:</strong> Nateglinide is a quick acting anti-diabetic medication whose potent activity lasts for a short duration. One of the dangerous side effects of nateglinide administration is rapid hypoglycemia, a condition that needs to be monitored carefully to prevent unnecessary fatalities. The aim of the study was to develop a longer lasting and slower releasing formulation of nateglinide that could be administered just once daily.</p> <p><strong>Methods:</strong> Matrix tablets of nateglinide were prepared in combination with the polymers hydroxypropylmethylcellulose (HPMC), eudragits, ethyl cellulose and polyethylene oxide and the formulated drug release patterns were evaluated using in vitro and in vivo studies.</p> <p><strong>Conclusion:</strong> Of the seventeen formulated matrix tablets tested, only one formulation labelled HA-2 that contained 15% HPMC K4M demonstrated release profile we had aimed for. Further, swelling studies and scanning electron microscopic analysis confirmed the drug release mechanism of HA-2. The optimized formulation HA-2 was found to be stable at accelerated storage conditions for 3 months with respect to drug content and physical appearance. Mathematical analysis of the release kinetics of HA-2 indicated a coupling of diffusion and erosion mechanisms. In-vitro release studies and pharmacokinetic in vivo studies of HA-2 in rabbits confirmed the sustained drug release profile we had aimed for.</p> <p><strong>Keywords</strong>: Hydroxypropylmethylcellulose, Matrix tablets, Nateglinide, Sustained release</p> Mohini Sihare, Rajendra Chouksey ##submission.copyrightStatement## http://jbpr.in/index.php/jbpr/article/view/559 Tue, 27 Nov 2018 13:38:31 +0000 SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF 3-FORMYL INDOLE BASED SCHIFF BASES http://jbpr.in/index.php/jbpr/article/view/561 <p>In order to develop new antimicrobial agents, a series of 3-formyl indole based Schiff bases were synthesized by reacting 3-formyl indole(indole-3-carboxaldehyde) with substituted aniline taking ethanol as solvent. The reaction was carried in the presence of small amount of <em>p-</em>toluene sulphonic acid as catalyst.All the synthesized compounds were characterized by IR, <sup>1</sup>H-NMR spectral analysis. All the synthesized compounds were evaluated for antimicrobial activity against two gram positive bacterial strains (<em>B. subtilis</em>and <em>S. aureus</em>) and two gram negative bacterial strains (<em>P. aeruginosa</em>and <em>E. coli</em>) and one fungal strain (<em>C. albicans</em>). All the synthesized compounds were found to have moderate to good antimicrobial activity. The&nbsp; standard drug amoxicillin, fluconazole were used for antimicrobial activity. Among the synthesized compounds, the maximum antimicrobial activity was shown by compounds GS04, GS07, GS08 and GS10.</p> Singh Gurvinder, Singh Prabhsimran, Dhawan R. K. ##submission.copyrightStatement## http://jbpr.in/index.php/jbpr/article/view/561 Tue, 04 Dec 2018 16:01:05 +0000