EVALUATION OF HEPATOPROTECTIVE ACTIVITY AND HISTOPATHOLOGICAL CHANGES IN LIVER OF ALBINO RATS TO FIND OUT THE EFFECT OF EXTRACT OF Sechium edule ROOTS AGAINST PARACETAMOL INDUCED HEPATIC DAMAGES

  • Mr. Bapi Ray Sarkar *, Prof. Biplab Kumar Dey

Abstract

The present study was conducted to evaluate the hepatoprotective activity of Ethanolic extract of Sechium edule against paracetamol induced liver damage in rats. The Ethanolic extract of Sechium edule (300mg/kg & 600mg/kg) was administered orally to the animals with hepatotoxicity induced by single dose of Paracetamol (2gm/kg). Silymarin (25mg/kg) was given as reference standard. All the test drugs were administered orally by suspending in 0.5% Carboxy methyl cellulose (CMC) solution. The Ethanolic extract of leaves of plant Sechium edule in the doses of 300mg/kg, 600mg/kg body wt, reduced the levels of serum SGPT, SGOT, ALP and Total bilirubin and increased the Total protein level significantly. In the histopathological studies of the liver section of rats showed the significant recovery with the Ethanolic extract of Sechium edule when compared with Control group and Paracetamol treated group.  

Keywords: Sechium edule, Paracetamol, Hepatoprotetive, Bilirubin.

Author Biography

Mr. Bapi Ray Sarkar *, Prof. Biplab Kumar Dey

The present study was conducted to evaluate the hepatoprotective activity of Ethanolic extract of Sechium edule against paracetamol induced liver damage in rats. The Ethanolic extract of Sechium edule (300mg/kg & 600mg/kg) was administered orally to the animals with hepatotoxicity induced by single dose of Paracetamol (2gm/kg). Silymarin (25mg/kg) was given as reference standard. All the test drugs were administered orally by suspending in 0.5% Carboxy methyl cellulose (CMC) solution. The Ethanolic extract of leaves of plant Sechium edule in the doses of 300mg/kg, 600mg/kg body wt, reduced the levels of serum SGPT, SGOT, ALP and Total bilirubin and increased the Total protein level significantly. In the histopathological studies of the liver section of rats showed the significant recovery with the Ethanolic extract of Sechium edule when compared with Control group and Paracetamol treated group.  

Keywords: Sechium edule, Paracetamol, Hepatoprotetive, Bilirubin.

Published
2016-10-30
How to Cite
Dey, M. B. R. S. *, P. B. K. (2016). EVALUATION OF HEPATOPROTECTIVE ACTIVITY AND HISTOPATHOLOGICAL CHANGES IN LIVER OF ALBINO RATS TO FIND OUT THE EFFECT OF EXTRACT OF Sechium edule ROOTS AGAINST PARACETAMOL INDUCED HEPATIC DAMAGES. Journal of Biomedical and Pharmaceutical Research, 5(5). Retrieved from https://jbpr.in/index.php/jbpr/article/view/126
Section
Research Articles