A Study of Serum Levels of Vitamin D in Impaired Glucose Tolerance and Type 2 Diabetes Mellitus

Abstract

The relationship between vitamin D and glucose metabolism has been a subject of intense research, particularly regarding its potential role in impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). This study aimed to examine the serum levels of vitamin D in patients diagnosed with IGT and T2DM. The study involved 100 participants, 50 with IGT and 50 with T2DM, all aged between 30 and 60 years. Serum vitamin D levels were measured using enzyme-linked immunosorbent assay (ELISA). The results showed a significant decrease in serum vitamin D levels in both IGT and T2DM groups compared to the healthy control group. Furthermore, a negative correlation was found between serum vitamin D levels and both fasting blood glucose and HbA1c levels, suggesting a potential link between low vitamin D levels and the severity of glucose intolerance. The findings imply that vitamin D deficiency may contribute to the development and progression of these metabolic disorders. Further studies are needed to confirm these results and to assess the potential therapeutic role of vitamin D supplementation in managing or preventing T2DM and IGT.

Keywords: Vitamin D, Impaired Glucose Tolerance, Type 2 Diabetes Mellitus, Glucose Metabolism, Insulin Resistance, Serum Levels.