Formulation and Evaluation of Bilayer Tablets of Lornoxicam for the Management of Pain

Abstract

The aim of present study was to formulate and evaluation of bilayer tablet for management of Pain Contacting Lornoxicam.

The Immediate release layer prepared by dry granulation method using sodium starch glycolate, cross povidone, aerosil, magnesium stearate, lake, microcrystalline cellulose and dicalcium phosphate are used. The sustained release layer prepared by wet granulation method using HPMC E50, PVPK30, eudragit, microcrystalline cellulose, talc, magnesium stearate and isopropyle alcohol. Both the layer was separately optimized and were prepared.

Optimized formulation F6 Over 42 % of levfloxacin s was released within the first 1 hour of dissolution study. This initial high amount of Lornoxicam can be attributed to the fast release layer of the formulation. Further release of Lornoxicam was studied for 12 hours. So it can be concluded that bilayer tablet of Lornoxicam which reduces pain incorporated in Immediate and sustain Layer.

Keywords: Bilayer tablet, HPMC, Lornoxicam, Dry granulation method, Sustained release.