Nanostructured Lipid Carriers of Econazole as a Strategy to Overcome Antifungal Resistance in Deep Skin Mycoses

Authors

  • Vikash Ghosalya Research Scholar, Jaipur College of Pharmacy, Jaipur
  • Lokesh Kumar Gautam Professor, Jaipur College of Pharmacy, Jaipur
  • Vikas Agarwal Professor, Jaipur College of Pharmacy, Jaipur
  • Parul Vaishnav Assistant Professor, Jaipur College of Pharmacy, Jaipur

DOI:

https://doi.org/10.32553/jbpr.v15i3.1469

Keywords:

Nanostructured Lipid Carriers

Abstract

Aim: This review evaluates nanostructured lipid carriers (NLCs) loaded with econazole nitrate as an advanced strategy to overcome antifungal resistance in deep skin mycoses.

Methodology: Literature from 2020–2026 on antifungal resistance, nanoparticle engineering, and AI/QbD-based formulation was critically analyzed.

Results: NLCs improved econazole solubility, skin penetration, encapsulation efficiency, and sustained release while bypassing fungal resistance mechanisms and biofilm barriers. AI and QbD approaches further optimized formulation development.

Conclusion: Econazole-loaded NLCs offer a promising nanotechnological platform for effective management of resistant deep skin fungal infections.

Keywords: Nanostructured Lipid Carriers, Econazole Nitrate, Deep Skin Mycoses, Antifungal Resistance, Biofilms, Dermal Drug Delivery.

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Published

2026-05-14

How to Cite

Ghosalya, V. ., Gautam, L. K. ., Agarwal, V. ., & Vaishnav, P. . (2026). Nanostructured Lipid Carriers of Econazole as a Strategy to Overcome Antifungal Resistance in Deep Skin Mycoses. Journal of Biomedical and Pharmaceutical Research, 15(3), 156–165. https://doi.org/10.32553/jbpr.v15i3.1469

Issue

Vol. 15 No. 3 (2026)

Section

Articles

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Copyright (c) 2026 Journal of Biomedical and Pharmaceutical Research

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