EVALUATION OF ANTI-HYPERTENSIVE ACTIVITY OF NORDOSTACHYS JATAMANSION AGAINST CADMIUM CHLORIDE INDUCES HYPERTENSION IN ALBINO RATS

Abstract

Nardostachysjatamansi is a very effective, potential and safe drug for the management of patients with essential hypertension along with dietary restrictions and modified lifestyle. The sesquiterpenevaleranone isolated from the subterranian parts of Nardostachysjatamansi (DC) is found to having sedative, tranquilizing and antihypertensive properties. Nordostachysjatamansiwhole plant was collected from herbal garden of National Institute of Ayurveda (NIA), Jaipur. Genuine sample of plant material was weighed by the electronic monopan balance and a thin layer of sample was spreaded on a white colour sheet. By bull lens, the layer was examined for foreign matter. Moisture content was determined by placing weighed sample of 5gm of Plant material in oven at 105ºC for 5 hours, and calculated weight of sample for every 30 minute. The pH value of an aqueous liquid may be defined as the common reciprocal of the hydrogen ion concentration expressed in gram per liter Freshly prepared extracts were tested for the presence of various active phytocompounds like phenols, tannin, Flavonoids, protein, reducing sugar, carbohydrates, lipids, Saponin, triterpenoid alkaloid, resins, volatile oils, anthraquinone and Quinone. Identification can be effected by observation of spots of identical RF value. Acute Toxicity Study (according to OECD 423 guideline). B. Anti-hypertensive activity (CdCl₂ Induced hypertension)

Keywords: Nardostachysjatamansi, Acute Toxicity, hypertensive activity, Ayurveda