FORMULATION DEVELOPMENT AND EVALUATION OF LIPOSOME FOR TOPICAL DELIVERY

Abstract

and side effects. So the objective of the present research work is to reduce the side effects, Topical administration of drug is better for local action and the efficiency of the topically administered drug is increased with vesicles like Liposomes. Liposomes were prepared by rotator evaporation method and optimized on the basis of average vesicle size, % drug entrapment and polydispersity index. The optimized formulation was further encorpoated with gel base (carbapol gel) and characterized for their viscosity, extrudability, spreadability and drug release study. The NSAIDs is mainly used for the treatment of rheumatoid arthritis and osteoarthritis. Sulfasalazine is non steroidal anti inflammatory drug with analgesic, antipyretic and anti inflammatory activity and it is commonly used in the treatment of acute mild to moderate pain, as well as inflammation of the joints caused by certain type of rheumatoid arthritis. The sulfasalazine drug has less bioavailability(10-30%), more dose frequency dose frequency, increase the bioavailability and  therapheutic efficacy.  So sulfasalazine is chosen for development of liposome preparation.

Keywords: Liposomes, rheumatoid arthritis, sulfasalazine