Journal of Biomedical and Pharmaceutical Research

An Assessment of Invitro Anti-Alzheimer Activity of Ammania Bacciferra Linn.

2024-05-31T17:17:27+00:00

Neurodegenerative disorders are characterized by the progressive and irreversible loss of neurons from specific brain areas. Alzheimer's disease (AD), where loss of hippocampal and cortical neurons impairs memory and cognitive function. From the literature review it was revealed that Ammania bacciferra linn. possess good antioxidant activity because of its active constituents and anti-oxidant may treat some neurodegenerative disorders. The main objective of this work is to identify the Alzheimer activity of Ammania bacciferra linn. Invitro activity was performed by Ellman method and IC50 Value was found to be 315 µg/mL Further extract was subjected for in vivo activity.

Keywords: Neurodegenerative disorders, neurons, Alzheimer's diseases. Memory enhancer.

Preliminary Pharmacognostical & Pharmacological Studies on The Pisonia Grandis R. Br. on Rats

2024-06-03T00:25:41+00:00

The plant Pisonia Grandis R.Br. belongs to the family Nyctaginaceae was taken up for the study by me to screening and gave a report on the possible Pharmacognostical and Pharmacological studies. The various ash values and extract values are determined. In Phytochemical screening showed the nature of the chemical constituents such as Alkaloids, Carbohydrates, Phenolic compounds, Protein and Amino acids, Saponins, Sterols, Flavonoids and Tanins present in the leaf extract of Pisonia Grandis R.Br. The LD50 of the aqueous and alcoholic extracts of Pisonia Grandis R.Br. leaves was found to be 2500 mg/kg. Therefore ED50 was calculated as 250 mg/kg. The Hepatoprotective activity was carried out by the Paracetamol induced model in rats. Administration of the aqueous and alcoholic extracts of Pisonia grandis R.Br. leaves showed significant hepatoprotective activity which was compared with the standared drug silymarin. The effect was more pronounced with the aqueous extracts Pisonia grandis R.Br., this may be probably due to the high contents of flavonoids.

Keywords: Pisonia grandis R.Br , Hepatoprotective, Histopathology, Paracetamol.

Design, Development and Evaluation of Oral Dissolving film of Montelukast Sodium

2024-06-08T00:41:27+00:00

Montelukast Sodium (MS) is widely used for managing asthma and allergic rhinitis due to its leukotriene receptor antagonist properties. However, traditional oral dosage forms often lead to challenges in patient compliance and delayed onset of action. This study focuses on the design, development, and optimization of oral dissolving films (ODFs) of Montelukast Sodium, aimed at improving patient compliance and ensuring rapid drug release. Using the solvent casting method, various formulations were prepared with different concentrations of hydroxypropyl methylcellulose (HPMC), Eudragit, and Xanthum Gum and plasticizers like polyethylene glycol (PEG). The films were evaluated for their thickness, drug content uniformity, disintegration time, in vitro dissolution, and mechanical properties. The optimized ODFs F5 demonstrated rapid disintegration (10 seconds) and high drug release (99.99% within 5 minutes), indicating their potential to enhance therapeutic efficacy and patient adherence.

Keywords: HPMC, Eudragit, Xanthum Gum, PEG, Film.

Formulation and Evaluation of Nanosuspension Containing Carbamazepine

2024-06-13T00:56:56+00:00

Carbamazepine (CBZ) is an antiepileptic drug with poor water solubility, which limits its bioavailability and therapeutic effectiveness. Nanosuspensions have emerged as a promising strategy to enhance the solubility and dissolution rate of poorly water-soluble drugs. This study aims to formulate and evaluate a nanosuspension of carbamazepine to improve its solubility and bioavailability. The nanosuspension was prepared using the wet milling technique, and various parameters such as particle size, polydispersity index (PDI), drug content, and in vitro dissolution were evaluated. The optimized nanosuspension exhibited a mean particle size of 120 nm, and PDI of 0.284 to 0.595 indicating good stability. The in vitro dissolution studies demonstrated a significant improvement in the release rate of carbamazepine from the nanosuspension compared to the pure drug. These findings suggest that nanosuspension is an effective approach to enhance the solubility and bioavailability of carbamazepine.

Key Words: Carbamazepine, Nanosuspensions, bioavailability, polydispersity index.

Evaluation of Drug Management of Essential Hypertension in Patients in the Sikar District (Rajasthan)

2024-06-15T01:01:23+00:00

Due to its terrific incidence and position as a key risk issue for cardiovascular illnesses and other effects, hypertension is a widespread public fitness challenge and an critical subject matter of research.To determine the management of hypertension and the factors that contribute to it. To gauge study participants' knowledge, access to care, and level of control over their hypertension. A cross-sectional study was performed in a hospital in Sikar District. An updated version of the WHO STEPS interview schedule was used for 200 patient, ages 20–60. 32% of people had hypertension at age 49 to 50. 58.3% of hypertensive patients were male. Male individuals who were the oldest had a higher likelihood of having hypertension. healthcare interventions are needed to enhance the management of high blood pressure on this location because of the higher incidence (30%-35%). nonpharmacological management is also an effective way to control hypertension, a lowering of mean SBP by >10 mm Hg and DBP by 5 mm Hg.

Evaluation and Standardization of Herbal Extract of Carum Copticum

2024-06-25T01:36:38+00:00

Plants are important and supplementary sources of drugs and Dietary. It can provide biologically active molecules which are used for treatments of different types of disease. The history of the medicinal plants is so important which explain the continuity and importance of medicated plants from generation to generation where and how it was discovered and who observed the medicinal importance in different era because the plants provide biologically active and important molecules that can be used for treatment of different disease. The present study was designed for the evaluation of herbal extracts for effective selection of plant material, standardization and extraction.

Keywords: Extracts, Standardization, Extraction.