Evaluation of Antifungal Potential of Syzygium cumini Ethosomal Gel

Abstract

The present study focuses on the development of a gel formulation incorporating leaf extract of Syzygium cumini L. and its evaluation for in-vitro anti-fungal activity. Syzygium cumini L. (Skeels), a widely cultivated medicinal plant, is known for its diverse pharmacological properties. In this investigation, ethosomal formulations of S. cumini extract were prepared and incorporated into a gel base. The anti-fungal efficacy of the formulation was assessed against Aspergillus flavus and Aspergillus niger using the agar well diffusion method. The results revealed a concentration-dependent increase in anti-fungal activity, with significant inhibition observed against A. niger. The performance of the gel formulation was compared with fluconazole, used as the standard reference at a concentration of 150 µg/mL. The S. cumini ethosomal gel demonstrated promising anti-fungal potential, suggesting its applicability as a natural therapeutic agent for fungal infections. Further studies are warranted to confirm its mechanism of action and efficacy in vivo.

Keywords: Syzygium cumini, ethosomal gel, anti-fungal activity, Aspergillus niger, Aspergillus flavus, agar well diffusion, fluconazole