Formulation and Evaluation of Nanosuspension Containing Carbamazepine

Shivam  Prajapati; Mayank  Bansal; Vikas  H; Rakesh Kumar  Gupta

doi:10.32553/jbpr.v13i3.1089

Shivam Prajapati Research Scholar, Jaipur College of Pharmacy, Jaipur, Rajasthan.
Mayank Bansal Prinicpal and Professor, Jaipur College of Pharmacy, Jaipur, Rajasthan.
Vikas H Assistant General Manager, Caplin Steriles Limited, Chennai.
Rakesh Kumar Gupta Professor, Jaipur College of Pharmacy, Jaipur, Rajasthan.

DOI: https://doi.org/10.32553/jbpr.v13i3.1089

Keywords: Carbamazepine, Nanosuspensions, bioavailability, polydispersity index.

Abstract

Carbamazepine (CBZ) is an antiepileptic drug with poor water solubility, which limits its bioavailability and therapeutic effectiveness. Nanosuspensions have emerged as a promising strategy to enhance the solubility and dissolution rate of poorly water-soluble drugs. This study aims to formulate and evaluate a nanosuspension of carbamazepine to improve its solubility and bioavailability. The nanosuspension was prepared using the wet milling technique, and various parameters such as particle size, polydispersity index (PDI), drug content, and in vitro dissolution were evaluated. The optimized nanosuspension exhibited a mean particle size of 120 nm, and PDI of 0.284 to 0.595 indicating good stability. The in vitro dissolution studies demonstrated a significant improvement in the release rate of carbamazepine from the nanosuspension compared to the pure drug. These findings suggest that nanosuspension is an effective approach to enhance the solubility and bioavailability of carbamazepine.

Key Words: Carbamazepine, Nanosuspensions, bioavailability, polydispersity index.