Hepatoprotective Activity of Sida Veronicaefolia against RIF+INH induce Hepatotoxicity in Experimental Animals

  • Arti Pandey Research Scholars, Department of Pharmacy, SunRise University, Alwar, Rajasthan
  • Vidhi Jain Research Scholars, Department of Pharmacy, SunRise University, Alwar, Rajasthan.
  • Manmeet Singh Saluja Professor, Department of Pharmacy, SunRise University, Alwar, Rajasthan.
DOI: https://doi.org/10.32553/jbpr.v12i1.953

Abstract

In the present investigation, rats will be given the liver-damaging drug RIF+INH, and the methanol (MESV) extract of the leaves of Sida veronicaefolia will be tested to see how well it protects the rats' livers from damage caused by RIF+INH. The hepatoprotective effects of MESV at a dose of 250 & 500 mg/kg were estimated by using liver function tests and serum profiles. According to the results, the extracts of Sida veronicaefolia at a dose of 250 & 500 mg/kg, not only have a strong hepatoprotective effect by lowering the levels of serum transaminases (SGPT and SGOT), alkaline phosphate, and total bilirubin in the blood, but they also increase the levels of total protein by a lot. The effects of MESV were very similar to those of silymarin, which is given as standard drug treatment.

Published
2023-01-24
How to Cite
Pandey, A., Jain, V., & Singh Saluja, M. (2023). Hepatoprotective Activity of Sida Veronicaefolia against RIF+INH induce Hepatotoxicity in Experimental Animals. Journal of Biomedical and Pharmaceutical Research, 12(1), 22-27. https://doi.org/10.32553/jbpr.v12i1.953
Issue
Vol. 12 No. 1 (2023)
Section
Articles

Copyright (c) 2023 Journal of Biomedical and Pharmaceutical Research

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Creative Commons LicenseJournal of Biomedical and Pharmaceutical Research by Articles is licensed under a Creative Commons Attribution 4.0 International License.