Optimization of Spirapril Controlled Release Floating Tablet Using 32 Central Composite Design

Abstract

The aim of present investigation was to develop efficient controlled release floating tablet (CRFT) of Spirapril. Floating dosage form for gastric retention has potential to use as controlled-release drug delivery systems which providing opportunity for both local and systemic drug action. The tablets were prepared by using wet granulation techniques using PVP K 30, SFG and Acrypol 934. A 3² full factorial design (CCD) was applied to optimize two independent variables at three different levels by varied response variables. Two independent variables i.e. amount of SFG (i.e., polymer X₁) and amount of Acrypol 934 (i.e., polymer X₂) were varied at three different levels that was coded for low, medium and high (-1, 0, 1 respectively). The response variables T₆ (cumulative % amount of drug released in 6 hr) (Y₁), T₁₂ (cumulative % amount of drug released in 12 hr) (Y₂), Q₅₀ (time in minutes required to 50 % of drug released) (Y₃), FLT (Y₄), TFT (Y₅), and Swelling Index after 12 hr (Y₆) were selected for present study. ANOVA study was also employed to optimize for best fitted quadratic model. Compressed matrices exhibited Super case-II transport drug release kinetics approaching zero- order, as the value of release rate exponent (n) varied between 0.9430 and 1.0133. Formulation A₄ was the optimized best formulation from the response surface plot and contour plot of all the formulation.