Lipidic, Protein and Polymeric Technology: An Updated Review

Abstract

In the field of pharmaceutical technology, lipids and polymers are regarded as essential excipients for the manufacture of most dosage forms. This is true regardless of the route of administration. They provide a variety of functions, including those of support vehicles, release rate modifiers, stabilizers, solubilizers, permeation enhancers, and transfection agents, among other responsibilities. This manuscript summarizes the fundamental roles of these two important classes of excipients, whether they are used alone or in combination, and provides insight on their functional properties in a variety of different types of drug formulations. The primary focus of this manuscript is on selected applications that were presented and discussed at the Annual Scientific Meeting of the Gattefossé Foundation in 2018. For the purpose of dispensing active medicinal substances that have poor permeability qualities or low water solubilities, oral formulations are given priority as the route of administration. In addition, this review paper discusses the use of lipids and polymers in the design of colloidal injectable delivery systems and as substrates in additive manufacturing technologies for the fabrication of tailor-made dosage forms. This topic is covered in both of those areas.

Keywords: Additive, Polymers, Manufacturing, Lipid, Pharmaceutical, Technology