ICU-BASED RESEARCH ON BACTERIAL PATHOGENS LINKED TO BLOODSTREAM INFECTIONS AND DRUG RESISTANCE

Abstract

Background: Multidrug resistant microbes are commonly found in intensive care units. For timely care, micro-biological diagnosis of bacteraemia is crucial; however, the findings of culture and antibiotic susceptibility testing take three to four days. It is crucial to furnish intensivists with up-to-date information regarding antibiotic susceptibility patterns in order to commence empirical therapy.

Methodology: The goal of this research was to determine the micro-biological profile of bloodstream infections (BSI) in subjects from the intensive care unit (ICU). The micro-biological characteristics, pattern of antibiotic susceptibility, and particular mechanism of antibiotic resistance of the isolates were investigated.

Results: Out of 300 subjects that were suspected, 22% had BSI. The most common isolates were A. Baumannii and P. aeruginosa, which exhibited MBL and ESBL synthesis as the main mechanisms of resistance.

Conclusion: Implementing a strong antibiotic strategy and adhering to hospital infection control measures is warranted due to the high prevalence of anti-microbial resistance in isolates causing bloodstream infections in intensive care units.

Key Words: Antibiotic resistance, blood stream infection, pathogens