Periodontitis Borne Risk Factors & Oral Health: A Pilot Study

Abstract

This study targets to earmark the risk factors that gets emerged in saliva and serum in the pathogenicity of periodontitis. ELISA based kits were used to estimate the risk components (TNF-a, IL-10 and IgA) in saliva and serum following company directed protocols. Colorimetry or spectrophotometry was used for the other estimations. Patients critically suffered from periodontitis, having pocket depth beyond 4mm, were found mildly affected with systemic hyperglycemia and dyslipidemia besides salivary hyperglycemia. The pro-inflammatory cytokine TNF-a  was found exorbitantly high in the saliva of the periodontitis affected subjects. No significant change of the anti-inflammatory cytokine (IL-10) was observed in the saliva except, a marginal increase in serum as compared to the control group. A remarkably low IgA level was found in both serum and saliva of the patients suffered from periodontitis. Blood groups of the subjects in this study didn’t show any correlation to the periodontitis infection. Females were found more vulnerable to periodontitis infection than the male counterparts. Lacking appropriate dental care could be the primary reason of making rooms for the settlement of microbes around teeth periphery causing periodontal pathogenicity.

Keywords: Periodontitis, TNF-α, IL-10, IgA, Oral infection