To Estimate Pregnancy Loss Rates after Mi Trimester Amniocentesis

Abstract

Background: Midtrimester amniocentesis, performed between 15 and 20 weeks of gestation, is a well-established procedure for diagnosing fetal genetic abnormalities. However, the potential risk of pregnancy loss following the procedure is a critical concern.

Objective: To estimate the pregnancy loss rates after midtrimester amniocentesis and identify factors contributing to this risk.

Methods: A retrospective cohort study was conducted at a tertiary care center, including women who underwent amniocentesis. Data on pregnancy outcomes (miscarriage and stillbirth), maternal age, and indications for amniocentesis were collected. The primary outcome was the rate of pregnancy loss within 24 weeks post-procedure.

Results: Of 1,500 women who underwent midtrimester amniocentesis, 12 cases of pregnancy loss were recorded, yielding an overall pregnancy loss rate of 0.8%. Increased loss rates were found among women aged 35 years and older and those with genetic concerns or abnormal screening results.

Conclusion: The risk of pregnancy loss after midtrimester amniocentesis is low (0.8%), though it is higher in older women and those with certain indications for the procedure. Counseling and informed decision-making are essential for women considering this procedure.

Keywords: pregnancy loss, amniocentesis, midtrimester, miscarriage, genetic disorders, prenatal diagnosis, maternal age