Synthesis and characterization of non-thiazolidinedione PPAR-γ agonists

Abstract

Based on the assumptions of QSAR studies performed on oximes and oximinoacetic acid derivatives, reduced CLogP value compounds P1 and P2 were designed. In the present work, laboratory synthesis of these compounds P1 and P2 was accomplished. Mitsunobu reaction principle was utilized for the synthesis of P1 whereas reduction of aldehyde was done for synthesis of P2. The formation of the products was evident from their NMR, mass and IR characterization which revealed the peaks relevant to the functional groups present in the compounds.

Keywords: oximes, oximinoacetic acid