CYTOPROTECTIVE EFFICACY OF DRDE-07 AND DRDE-30 AGAINST CISPLATIN INDUCED NEPHROTOXICITY

Abstract

Aim: The objective of the study was to investigate the cytoprotective action of DRDE-07 and DRDE-30 against cisplatin induced nephrotoxicity in mice.

Subjects and Methods: Randomly bred Swiss female mice (25-30 g) were selected and were divided into five groups (n = 6). Group I treated as control (distil water); Group II were administered Cisplatin at 10mg/kg. And Group III were administered Cisplatin at 10mg/kg and  Amifostine (185 mg/kg), Group IV were administered with  Cisplatin (10 mg/kg) and DRDE-07 at 249 mg/kg, Group V were administered with  Cisplatin (10 mg/kg) and DRDE-30 at 219 mg/kg body weight. Two experiment designs were planned. In first design, drug was given 30 min before administration of cisplatin and followed by three days orally. In second design the drug was given after administration of cisplatin and the rest was same as first design.

Results: Various biochemical parameters had been done on the plasma samples collected from experimental animals exposed to cisplatin through intraperitonial route as well as control and drug groups. It was noticed in the present investigation there was a significant increasement in urea and creatinine value in cisplatin group. it was observed that the pre-treatment of DRDE-07 and DRDE-30 showed efficacy against cisplatin induced nephrotoxicity. the post-treatment is also effective in case of DRDE-07 not for DRDE-30.

Conclusions: It was concluded that the DRDE-07 and DRDE-30 showed much effectiveness when given before the exposure of cisplatin.

Keywords: Cisplatin, DRDE-07, DRDE-30, Cytotoxicity, Cancer, Nephrotoxicity,