SEROFREQUENCY OF HEPATITIS D VIRUS AMONG HEPATITIS B VIRUS INFECTED PATIENTS ATTENDING TO TALODI HOSPITAL, SOUTH KORDOFAN STATE, SUDAN.

Mokhtar Zakaria Adam Salih*1, Wafa Ibrahim Elhag**2, Raja Yagoub El Feel*** Hamza Abdallh****4

Mokhtar Zakaria Adam Salih*1, Wafa Ibrahim Elhag**2, Raja Yagoub El Feel*** Hamza Abdallh****4 *1-Talodi hospital, Laboratory department, South Kordofan, State, Sudan. **2-Assistant professor, Faculty of Medical Laboratory Sciences, Al Neelain University, Sudan. ***3-Ministry of Health, Khartoum, State, Sudan. ****4- Ministry of Health, Virology lab, Khartoum, State, Sudan.

Abstract

Background: Hepatitis Delta Virus (HDV) infects only patients that are already infected by hepatitis B virus (HBV) because this is sub satellite virus which depends on and propagate only in the presence of HBV. HDV causes co-infection or super infection with sever complication as compared to only HBV infection. There is no published data in Sudan, therefore, our study aimed to detect serofrequency of hepatitis D among hepatitis B infected patients.

Methods: This is across sectional study included HBV infected patients aged between (11-54) years old with mean 30.4 years old conducted Talodi hospital, South Kordofan, State, Sudan, during February to May 2014.

We performed HDV serum marker, was detected using commercially available enzyme-linked immunosorbent assay kit. Generated data were analyzed by using SPSS program.

Results: A number of 90 patients who were HBsAg positive, attending Talodi hospital, South Kordofan, State, Sudan, were included in this study, their age range (11-54) years old, out of them 24(26.7%), were positive for HDV IgG. From them 11(12.2%) males and 13(14.4) were females. The seropositivity of HDV had associated with risk factors of positive family history, cupping, surgery, and dental surgery. This study shown statistically significant relationship between gender and seropositivity of HDV infection (p=0.03). However, there was no significant relationship between risk factors and HDV.

Conclusion: the seropositivity of HDV among HBsAg is higher in Talodi. Further confirmation and mentoring with large scale specimen is recommended.

Key words: Anti-HDV, Talodi Hospital, South Kordofan State, Serofrequency, ELISA.