DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE DETERMINATION OF ZALTOPROFEN IN BULK AND PHARMACEUTICAL TABLET DOSAGE FORM

  • Purnima Gandi*, Dr.Y. Srinivasa Rao, K. Vara Prasada Rao T. Hemanth Kumar Department of Pharmaceutical Analysis and Quality Assurance, Vignan Institue of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam-530 049

Abstract

A new RP-HPLC method was developed and validated for determination of Zaltoprofen in bulk and tablet dosage form. The estimation was carried out on Enable C18G (250 mm ×4.6 mm, 5 µm) column using Acetonitrile and Water in the ratio of 95:5 (v/v) as mobile phase. The flow rate was 1.0 ml/min and the effluent was monitored by UV detector at 331 nm. The retention time was 3.653 min and linearity was observed in the concentration range of 10-50 µg/ml. The percentage recovery was in good agreement with the labelled amount in the pharmaceutical formulation and the method was simple, precise and accurate for the determination of Zaltoprofen in bulk and pharmaceutical formulation.

Key words: Zaltoprofen, RP-HPLC, Validation

 

Published
2015-02-28
How to Cite
T. Hemanth Kumar, P. G. D. S. R. K. V. P. R. (2015). DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE DETERMINATION OF ZALTOPROFEN IN BULK AND PHARMACEUTICAL TABLET DOSAGE FORM. Journal of Biomedical and Pharmaceutical Research, 4(1). Retrieved from http://jbpr.in/index.php/jbpr/article/view/161
Issue
Vol. 4 No. 1 (2015)
Section
Research Articles

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