ASSESSMENT OF HYPERCOAGULABILITY STATE AMONG SUDANESE SICKLE CELL PATIENTS

Abstract

Sickle cell anaemia is one of the causes of morbidity and mortality in Africa. This study aimed to determine the coagulation profile, including D-Dimer level, Fibrinogen level and TAT, and also to determine haematolgical feature of sickle cell anaemia in Sudan. The study included 100 Sudanese patients with sickle cell anaemia: 66 patients in a steady state and 34 in vaso-occlusive crisis. Their coagulation profiles and haematological parameters were measured and compared with 50 age and sex matched normal subjects as control, who attended Gaafer Ibn Auf hospital in Khartoum state, Sudan. Lower Hb level and higher TWBC count was observed among SCA patients when compared with controls (p value 0.000). Mean D-Dimer level, fibrinogen level and TAT were significantly higher among SCA cases in steady state than controls (p value 0.000, 0.000 and 0.005 respectivly). Further increases in D-Dimer level, fibrinogen level and TAT were observed among SCA patients with vaso-occlusive crisis than those in steady state (p value 0.000 for all parameters).
Conclusion: SCA is associated with reduction of Hb and increased of D-Dimer, fibrinogen and TAT level and may be used as probable indicator for hypercoagulability state which may lead to thrombotic complications.
Key words: SCA, D-Dimer, Fibrinogen, TAT. Sudan