STUDIES ON AN AMIDE BASED MUTUAL PRODRUG: SYNTHESIS AND EVALUATION

  • Asif Husain1*, Aftab Ahmad2, Shah Alam Khan3 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard University, New Delhi-110 062, India 2Jeddah Community College, King Abdul Aziz University, Jeddah 21589, Kingdom of Saudi Arabia 3Department of Pharmacy, Oman Medical College, Muscat, Sultanate of Oman

Abstract

The aim of this study has been to prepare a useful drug, which could have broad spectrum of antimicrobial activity including antitubercular action. Thus, an amide-based mutual prodrug (NA-INH) was synthesized by condensing isoniazid with nalidixic acid following single-step synthesis. Its structure was established on the basis of elemental analysis, 1H NMR and Mass spectral data results. The mutual prodrug (NA-INH) was also evaluated for in-vitro antibacterial activity including anti-mycobacterial and antifungal activity.
Key words: Nalidixic acid, amide, prodrug, antibacterial, antiTB.

Published
2015-04-30
How to Cite
Shah Alam Khan3A. H. A. A. (2015). STUDIES ON AN AMIDE BASED MUTUAL PRODRUG: SYNTHESIS AND EVALUATION. Journal of Biomedical and Pharmaceutical Research, 4(2). Retrieved from http://jbpr.in/index.php/jbpr/article/view/182
Issue
Vol. 4 No. 2 (2015)
Section
Research Articles

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