WOUND HEALING ACTIVITY OF AQUEOUS AND ETHANOLIC EXTRACT OF HOUTTUYNIA CORDATA LEAVES IINDIGENOUS TO NORTH-EAST INDIA

Vinod Kumar Verma1*, Manas Pratim Boruah2, Manju Bais3, Bankim Chandra   Nandy4

Vinod Kumar Verma1*, Manas Pratim Boruah2, Manju Bais3, Bankim Chandra Nandy4 *1Department of Pharmaceutical Science, Dibrugarh University, Dibrugarh, Assam, India 2 Department of Chemistry, Silapathar Science College, Silapathar, Dhemaji, Assam, India 3Department of Anthropology, Pt. Ravi Shankar Shukla University, Raipur, (C.G.) India 4Department of Pharmaceutical Science, Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Abstract

The present study objective are to investigate indigenous plant used in wound healing in northeast India, we hereby reported our findings related to wound healing activities of plant leaves extracts from in vitro and in vivo model in rats. The aqueous and ethanol extracts of the leaves of H. cordata was tested for phytochemical constituents and wound healing activity against rats. The animals were divided into four groups with six rats in each group. Topically applied 10% w/v of plant H. cordata leaves extracts in saline taking 0.2% w/w nitrofurazone, ointment as standard. The ethanol extract of H. cordata leaves on topical application significantly reduced the epithelization period as well as decrease in the scar area. The tensile strength and hydroxyproline content of plant extract treated group significantly increased when compared with control and standard group animals. The finding of studies revealed that the plant has potential wound healing activity and to justify the traditional use in wound healing in India.

Keywords: Excision; Incision; Houttuynia cordata; Epithelization period; Scar area