Expression of Her2/neu in Histological Sections of Sudanese Serous and Mucinous Ovarian Carcinoma

Abstract

Background: HER2/neu over expression may be of some prognostic importance in advanced  ovarian carcinoma; its role in early-stage disease has not been established. The current study examined the prevalence and significance of HER2/neu expression in different grades of different types of ovarian carcinoma in Sudanese patients.

Objectives: this study aimed to examine the prevalence and significance of HER2/neu over expression in different grades of different types of ovarian carcinoma in Sudanese patients.

Materials and Methods: Representative sections from formalin-fixed paraffin embedded tissue blocks were taken from 40 blocks collected from TOTAL LABCARE and POLICE hospital in Khartoum state in Sudan. Her2/neu immunohistochemistry were done on 40 samples of patient with ovarian carcinoma.

Results:  Immunohistochemical staining performed in the total number of 40 cases, 20 cases were mucinous ovarian carcinoma, and 20  cases were serous ovarian carcinoma, the result showed that positive staining of her2/neu in 3 cases of mucinous and negative staining in 17 cases 85%  of the mucinous carcinoma, and also showed  positive staining   in one case of serous carcinoma and negative staining in 19 cases 95%.                                                                                                                                              

Conclusion: According to these finding we conclude that the frequency of overexpression and amplification of   her2/neu is poor in types and grades of Sudanese ovarian carcinoma

Key words: Ovarian Cancer, her2/neu Sudan