MICROBIOLOGICAL PROFILE AND ANTIBIOTIC SUSCEPTIBILITY PATTERN OF UROPATHOGENS IN ANAND DISTRICT OF GUJARAT, INDIA.

Abstract

Background: Antimirobial drug resistance in urinary tract pathogens is a challenging problem to the medical practitioners & important reason for increased morbidity and healthcare expenditure.

Aim/Objective: To document prevalence of pathogens in Urinary Tract infections (UTIs) and their current antimicrobial susceptibility pattern in Anand region of Gujarat, India.

Materials and Methods: Urine samples from symptomatic UTI cases were processed. Bacterial isolates were identified using standard methods and AST was performed by disc diffusion methods as per CLSI guidelines (2012).

Results: A total of 954 consecutive urine specimens from symptomatic UTI cases were processed.378 samples showed significant bacteriuria. Antimicrobial susceptibility pattern of isolates were studied for 26 different antimicrobials of different classes. Among uropathogens isolated, E.coli was found predominant (51.9%) followed by Klebsiella spp (18.3%), Pseudomonas spp (17.2%), Proteus spp (3.2%), S. saprophyticus (2.6%) Enterobacter spp (1.3%), Providencia spp (05%), Yeast (3.2%), Staphylococcus aureus (1.6%) and Alcaligenes spp (0.3%). Out of antimicrobials tested Ampiillin (92.3%), Cefpodoxime (89.3%),  Amoxyclave (84.7%), Piperacillin (84.4%) and Cefotaxime (83.6%), Ceftazidime (73.8%) have shown highest resistance by different uropathogens. Aminoglyciosides, Carbapenem and 3rd/4th generation fluroquinolones showeded low resistance.

Conclusion: E.coli was found to be the most dominant uropathogen in this region, prevalence of Pseudomonas spp was also found comparatively higher. There has been a fairly high level of drug resistance among the uropatogens isolated. 

Key-words: Uropathogen, Antibiotic Sensitivity Pattern, Prevalence, Anand, Drug resistance