Effect of TonEBP on cardiovascular manifestations; influence of signaling mediators

  • Manoj G Tyagi + , Pulastya Vora*, K N Anand+, Aniket Kumar+ Department of Pharmacology+ Christian Medical College, Vellore 632002, TN & Pharmaceutical Consultants Pvt. Ltd *, Ahmedabad, Gujarat

Abstract

Tonicity-responsive enhancer binding-protein (TonEBP or NFAT5), which belongs to the Rel/NFAT family of transcription factors, plays a critical role in the kidney by controlling the expression of osmoprotective genes including heat-shock protein 70 and genes that mediate the intracellular accumulation of small organic osmolytes that reduce intracellular ionic strength without affecting protein function, such as aldose reductase (AR), sodium-chloride-betaine cotransporter (BGT1), and sodium-myo-inositol cotransporter (SMIT). Numerous cell types throughout the body are exposed to aniosmotic environments. Environmental osmolality is greatest in the kidney where levels as high as 1200 mOsmol/kg can be reached at the tip of the inner medulla in humans. This review examines the importance of TonEBP on cardiovascular manifestations and influence of signaling molecules.
Key words: TonEBP, Heart, SUMO, vascular, kidney, dopa decarboxylase

Published
2017-10-30
How to Cite
K N Anand+, Aniket Kumar+M. G. T. +. , P. V. (2017). Effect of TonEBP on cardiovascular manifestations; influence of signaling mediators. Journal of Biomedical and Pharmaceutical Research, 4(5). Retrieved from http://jbpr.in/index.php/jbpr/article/view/223
Issue
Vol. 4 No. 5 (2015)
Section
Review Articles

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