BIOLOGICAL EVALUATION OF 2-ARYLIDENE-4-(METHOXYPHENYL)BUT-3-EN-4-OLIDES

  • Mohammad Maaz1, Aftab Ahmad2, Shah Alam Khan3, Asif Husain4* 1Faculty of Medicine (Unani), Jamia Hamdard (Hamdard University), New Delhi-110062, India 2Health Information Technology Department, Jeddah Community College, King Abdulaziz University, Jeddah-21589, KSA 3Dept of Pharmacy, Oman Medical College, PO Box 620, PC 130, Muscat, Sultanate of Oman 1Dept of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India

Abstract

A series of 2-Arylidene-4-(methoxyphenyl)but-3-en-4-olides were screened against Pheretima posthuma earthworm for anthelmintic activity. The in vitro effects of compounds were evaluated at a concentration of 2mg/mL and time taken by the compounds to paralyze and subsequently kill the worms was recorded. Butyrolactone derivatives exhibited moderate to good anthelmintic activity but among all tested compounds, compound II, 2-(3,4,5-trimethoxy-benzylidene)-4-(methoxyphenyl)but-3-en-4-olide, was found to be the most potent against Pheretima posthuma. The anthelmintic activity of compound II was observed to be comparable with positive control albendazole in terms of paralytic and lethal time. Keywords: Furnaone, Butyrolactone, Pheretima posthuma, Anthelmintic.

Published
2017-10-30
How to Cite
Asif Husain4*M. M. A. A. S. A. K. (2017). BIOLOGICAL EVALUATION OF 2-ARYLIDENE-4-(METHOXYPHENYL)BUT-3-EN-4-OLIDES. Journal of Biomedical and Pharmaceutical Research, 4(5). Retrieved from http://jbpr.in/index.php/jbpr/article/view/225
Issue
Vol. 4 No. 5 (2015)
Section
Research Articles

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