Pulmonary hypertension; aetio-pathogenesis, current treatment and future prospects

Abstract

Pulmonary hypertension (PH) is a vascular disorder characterized by pulmonary vascular remodeling and increased pulmonary vascular resistance, ultimately resulting in pressure overload, dysfunction, and failure of the right ventricle. Current medications for PH do not reverse or completely prevent disease progression, and current diagnostic strategies are suboptimal for detecting early-stages of the disease. One way to optimise the management of PH patients is the use of combination therapy. Another approach to the optimisation of PH management is the development of novel treatments and therapeutic strategies that will provide further opportunities to improve outcomes for PH patients. This article discusses the current and recent advancements in the aetio-pathogenesis and treatment of this disorder.  

Keywords: Pulmonary, hypertension, endothelin, nattokinase, blood pressure, connective