THE POSSIBLE PROPHYLACTIC EFFECT OF EGYPTIAN MORINGA OLEIFERA SEED OIL AS ANTI-ULCER ACTIVITY AND ANTI-INFLAMMATORY IN RATS.

Abstract

Moringa oleifera Lam. is the multipurpose tree (therapeutic potential and nutritive value). In this work, authors focused on importance of Moringa oleifera seed oil (MSO) as antioxidant, anti-inflammatory and antiulcer. The search describes the lethal dose of 50 % (LD50), some Physico-chemical, antioxidant, antiulcer and anti-inflammatory of MSO. The results illustrated that the LD50 of MSO is more than 62.5 g/kg. MSO treated animals (250 and 500 mg/kg) a significantly decreased in the gastric juice, free acidity(FA) and total acidity (TA), also occurs improvement in pH of gastric juice(PH). There was a significant anti-ulcer activity, in ethanol-induced gastric ulcer of the MSO treated groups compared to ranitidine (R)( 197 mg/kg )as standard. Also, MSO (20 mg/kg, 72%) inhibited the carrageenan-induced inflammation in the hind paw of rats compared with ibuprofen (20 mg/kg, 33%) and mefenamic acid (100 mg/kg, 39%) as standard. Keywords: lethal dose of 50 %, ibuprofen, Moringa oleifera Lam., pylorus ligation, antiulcer activity, anti-inflammatory.