ROLE OF OMEGA-3 FATTY ACID IN HEPATOPROTECTION AGAINST CARBON TETRA CHLORIDE INDUCED LIVER INJURY IN ALBINO RABBITS

  • Renu Khanchandani*1, Sheo Pratap Singh 2, Asha Agarwal 3 1. Department of pharmacology, Assistant professor, Govt. Medical College Haldwani, Kumaun University, Nainital, India 2 Department of pharmacology, Professor, G.S.V.M. Medical College Kanpur, C.S.J.M. University Kanpur, India 3 Department of pathology, Professor, G.S.V.M. Medical College Kanpur, C.S.J.M. University Kanpur, India

Abstract

In the present study hepatoprotective activity of Omega-3-fatty acid against carbon tetrachloride (CCl4) induced hepatic damage in albino rabbits was evaluated. Hepatic injury was induced by administering 0.05ml/Kg body wt. intraperitoneally of CCl4. Omega-3-fatty acid at dose levels of 600 mg/Kg/day were administered to albino rabbits that showed protection from hepatic injury. Omega 3-fatty acid reduced the elevated serum liver enzymes like Aspartate Transferase (SGOT), Alanine Transferase (SGPT), Alkaline Phosphatase (ALP) and serum bilirubin. The result obtained were compared with silymarin (100 mg/Kg body wt. p.o), the standard drug. In conclusion omega-3-Fatty acid (600 mg/Kg/day) were found to hvae very highly significant (p<0.001) hepatoprotective activity comparable to silymarin.

Key words: Omega-3-Fatty acids, Carbon tetra chloride, Hepatoprotective activity, Silymarin

Published
2014-12-30
How to Cite
Asha Agarwal 3R. K. S. P. S. 2. (2014). ROLE OF OMEGA-3 FATTY ACID IN HEPATOPROTECTION AGAINST CARBON TETRA CHLORIDE INDUCED LIVER INJURY IN ALBINO RABBITS. Journal of Biomedical and Pharmaceutical Research, 3(6). Retrieved from http://jbpr.in/index.php/jbpr/article/view/331
Issue
Vol. 3 No. 6 (2014)
Section
Research Articles

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