DESIGN AND EVALUATION OF TAZAROTENE LOADED LIPOSOME GEL FOR EFFECTIVE TREATMENT OF PSORIASIS AND ACNE

Abstract

Topical Tazarotene  is  a  widely  used  drug  in  the  topical treatment  of  Acne,  Psoriasis  and  other skin disorders. Tazarotene synthetically produced retinoid commonly used in the treatment of acne. Tazarotene is a pro-drug of tazarotenic acid, a receptor-selective retinoid, which has shown efficacy in the treatment of these disorders. In the treatment of acne vulgaris, it has greater comedolytic activity than the currently available topical retinoids. In psoriasis, tazarotene normalizes keratinocyte differentiation, reverses keratinocyte hyperproliferation and has better anti-inflammatory effects than any of the currently available topical retinoids. But topical treatment with Tazarotene reported certain side effects. Approximately, 10 to 30% of patients experience peeling, dryness, irritation and burning with its use, mostly during the early weeks of therapy. Liposomal drug delivery strategies can play a pivotal role in improving the topical delivery by enhancing their dermal localization with a concomitant reduction in their side effects. Liposomes composed of Soya lecithin and cholesterol, with Tazarotene entrapped in the inner water compartment, were prepared by the simple mechanical method vortexing the phospholipid dispersion in water. Topical liposome gels will be prepared by incorporation of liposomes into a structured vehicle (1.5, 1.75 and 2 % Carbopol gel base). Also, corresponding hydrogels were prepared and drug release properties were investigated.

Keywords:  Tazarotene, acne vulgaris, psoriasis, Liposomes