SOLUBILITY ENHANCEMENT OF LERCANIDIPINE HYDROCHLORIDE BY COCRYSTALLISATION.

  • *Asija Rajesh1, Mangukia Dhruv2, Asija Sangeeta2, Patel Jaimin2, Patel Chirag J2, Patel Pinkesh2 1Professor & Principal, Maharishi Arvind Institute of Pharmacy, Mansarover, Jaipur, Rajasthan, India-302020. 2Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020

Abstract

In this study, the significant effect of malonic acid on enhancement of solubility of lercanidipine hydrochloride by simple solvent change process has been demonstrated. Malonic acid and lercanidipine hydrochloride were simultaneously crystallised using water as anti-solvent. The pure drug and different concentrations of malonic acid were characterized in terms of solubility, percentage yield, melting point, crystallinity, thermal behaviour, compatibility studies and surface morphology. The optimised cocrystal formulation exhibited enhancement in aqueous solubility.

 

KEY WORDS: Lercanidipine Hydrochloride, Cocrystals, Solvent Change Approach, Solubility Enhancement.

Published
2013-06-28
How to Cite
Chirag J2, Patel Pinkesh2 *Asija R. M. D. A. S. P. J. P. (2013). SOLUBILITY ENHANCEMENT OF LERCANIDIPINE HYDROCHLORIDE BY COCRYSTALLISATION. Journal of Biomedical and Pharmaceutical Research, 2(3). Retrieved from http://jbpr.in/index.php/jbpr/article/view/377
Issue
Vol. 2 No. 3 (2013)
Section
Research Articles

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