EFFECT OF POSTMENOPAUSAL STATUS ON SERUM LIPIDS PROFILE AND URIC ACID IN SUDANESE FEMALES FROM THE GENERAL POPULATION

Abeer Bashir1, AbdElkarim A. Abdrabo*2

Abeer Bashir1, AbdElkarim A. Abdrabo*2 1 Department of Clinical chemistry, Faculty of Medical Laboratory Sciences, Sudan International University- Sudan 2 Department of Clinical chemistry, Faculty of Medical Laboratory Sciences, Al Neelain University - Sudan

Abstract

BACKGROUND: Previous data suggest possible effects of postmenopause on serum lipids profile and uric acid which are established risk factors for cardiovascular system.

AIM: to evaluate the changes that may occur on serum lipids profile and uric acid measurements in postmenopausal Sudanese women.

MATERIALS AND METHODS The study involved 150 females. The studies subjects were grouped according to their menstrual status to women at age of menarche (75 women) their age ranged between (45 – 90 years, mean of 59.1), and women at age after menopause (75 women) aged between (25 – 49 years, mean 35.9). Following at least 12 hours fasting, serum total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), and uric acid were measured.

RESULTS: lipids measurements were significantly different in both groups; HDL-cholesterol was significantly less in postmenopausal women (M±SD = 45.2±13.76 mg/dl) compared to women at age of menarche (M±SD = 51.8±14.9 mg/dl, P = 0.032). TC, LDL, and UA concentrations are significantly increased in postmenopausal women (171±19.6 mg/dl, 120.5±19 mg/dl and 5.0±0.8 mg/dl) compared with women at age of menarche (149.2±25.7 mg/dl and 94.7±10.1 mg/dl, and 3.66±0.7, P = 0.000, 0.002, and 0.001 respectively).

CONCLUSION: two possible cardiovascular risk factors may present in postmenopausal women hyperlipidaemia and increased uric acid, so screening is necessary to women at this age.