Standardization of the Standards: A Novel Idea in Clinical Biochemistry Review with Special Reference to Developing Countries

Abstract

Objective: The principle of Physical Chemistry applies equally to the metabolic reactions or activities. The proportionality of the law of mass action of reactants and products indicates a linear decrease in the values, if low doses of reactants are used, as in developing countries. The main aim of the present study is to evaluate and redefine the standard normal values of biochemical parameters in context of developing countries.

                Methods: Standard evaluation procedures were used for detection of common biochemical parameters in normal healthy individuals. The results are compared with the standard normal values of existing/established biochemical normal values.

                Results: The results showed marked variation in normal values and after evaluation and comparison of the ranges it was found to be different in the study.

                Conclusion: Normal biochemical values are markedly different in cases of samples from developing countries and the comparison and detection and diagnosis will have to be evaluated based on the newly developed normal values for better and appropriate diagnosis, in developing countries.