Evaluation of Binding Property of Ocimum Tenuiflorum Linn. Seed Mucilage Isolated By Defatting Method.

Abstract

In the present study Ocimum Tenuiflorum Linn seed mucilage was evaluated to determine if it posseses the tablet binding property. For this purpose the seed mucilage was used in different concentrations as binder in the formulations and compared with tablet prepared with starch as binder. Six tablet formulations were prepared in which F1 to F5 contained 1-5 % ocimum seed mucilage and F6 contained 5 % starch. These tablets were evaluated for hardness, thickness, friability, disintegration, content uniformity, in vitro drug release. The results indicated that mucilage is required in less concentration to give equivalent binding effect produced by starch in 5 %. Thus ocimum seed mucilage shows potential to use as binder in tablet formulations in lesser concentration than starch which may the cut cost of formulation to some extent.

KEYWORDS: Tablet binder, seed mucilage, defatting method, ocimum Tenuiflorum