In Vitro Release Kinetics Study of Indomethacin 12Hr Matrix Tablet From Methocel K4M CR and Methocel K15M CR.

Abstract

The objective of the present study was to design and evaluate controlled release tablets of Indomethacin, employing release retarding materials semi synthetic polymers Methocel K4M CR and Methocel K15M CR. There were nine formulations (F1-F9), were prepared in different ratios of Methocel K4M CR and Methocel K15M CR used as release retarding agents and Starch 1500 & Lactose Monohydrate were used as diluents. Tablets were prepared by direct compression method. The powders for tableting were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity etc. The tablets were subjected to thickness, weight variation test, hardness, friability and in vitro release studies. Release profile of Indomethacin from this sustained release matrix tablet was investigated at dissolution media (Phosphate buffer PH 6.8) using USP Apparatus-2 for twelve hours. The drug release patterns were simulated in different kinetic orders such as Zero Order release kinetics, First Order release kinetics, Higuchi release kinetics, Korsmeyer-Peppas release kinetics and Hixson-Crowell release kinetics to assess the release mechanism. From the study we observed that Higuchi release kinetics, Korsmeyer-Peppas release kinetics and Hixson-Crowell release kinetics were the predominant release mechanism than Zero Order and First Order kinetics. The drug release mechanism from the matrix tablets was found to be non Fickian mechanism.

KEY WORDS: Indomethacin, Sustained Release, Methocel K4M CR, Methocel K15M CR