A short Review on Stomach Specific Floating in-situ gel

Abstract

Oral drug delivery is a one of the simplest routes of delivery of drugs for systemic and in certain cases local effect. Liquid oral dosage forms are convenient to administer as compared to solid dosage forms but cannot achieve sustained effect due to less residential time in gastrointestinal tract. In-situ gel provides the best way to overcome problems of immediate release and short gastrointestinal residence of liquids. The in situ gel dosage form is a liquid before administration and after it comes in contact with gastric contents due to one or more mechanisms gets converted to gel which floats on gastric contents. This achieves increased residence as well as sustained release. This approach is useful for systemic as well as local effect of drugs administered. This review gives a short idea about floating oral in-situ gel formation and research done by various scientists on a number of drugs and polymers.

KEY WORDS: Oral, In-situ gel, Floating drug delivery.