Effect of quercetin on estrogen receptor α and β expression in uterine tissues in ovariectomized rats

quercetin regulated uterine estrogen receptor expression

  • Chunzhen Zhao Weifang Medical University
  • Lin Wang Key Lab of Applied Pharmacology in Universities of Shandong, Weifang Medical University, Weifang, 261053, China
  • Shumei Wang Key Lab of Applied Pharmacology in Universities of Shandong, Weifang Medical University, Weifang, 261053, China
  • Xiaofan Guo Department of Pharmacy, Weifang Nursing Vocational College, Weifang, China
  • Haijian Li Department of Pharmacy, Weifang Nursing Vocational College, Weifang, China
  • Yanna Lv Key Lab of Applied Pharmacology in Universities of Shandong, Weifang Medical University, Weifang, 261053, China
Keywords: ovariectomy; estrogen receptor, quercetin

Abstract

`Objective To explore the effect of quercetin on mRNA expressions of estrogen receptor α (ERα) and estrogen receptor β (ERβ) in ovariectomized (OVX) Sprague-Dawley (SD) rats. Method Thirty-two SD rats were randomly divided into 4 groups: sham group, ovariectomy group, quercetin group and estradiol group. The mRNA expression of ERα and ERβ in the uterus were determined by RT-PCR. The level of estradiol (E2) in the plasma was detected by ELISA. Results After ovariectomy, uterus coefficient, serum estradiol level and the mRNA expression of ERα and ERβ in the uterus were markly decreased in OVX rats. After treatment with quercetin, uterus coefficient, serum estradiol level and the mRNA expression of ERα and ERβ in the uterus were significantly increased. Conclusion Quercetin can improve menopausal syndrome in the OVX rats through regulating estrogen release and receptor expression.

Published
2018-06-28
How to Cite
Zhao, C., Wang, L., Wang, S., Guo, X., Li, H., & Lv, Y. (2018). Effect of quercetin on estrogen receptor α and β expression in uterine tissues in ovariectomized rats: quercetin regulated uterine estrogen receptor expression. Journal of Biomedical and Pharmaceutical Research, 7(03). Retrieved from http://jbpr.in/index.php/jbpr/article/view/539
Issue
Vol. 7 No. 03 (2018)
Section
Research Articles

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