SOLUBLITY ENHANCEMENT OF FLUCONAZOLE BY FORMULATION OF HYDROTROPIC SOLID DISPERSIONS

  • Anu Kaushik*, Rakesh Kumar Jat

Abstract

In the present research work mixed hydrotropic solubilization phenomenon is used to enhance the solubilization of poorly water soluble drugs. Bulk drug samples were identified by the observed IR spectra and the melting points determination. Sodium benzoate, niacinamide and urea are the hydrotropes were selected for the solubility enhancement of drugs Solubility enhancement ratios for selected poorly water-soluble drugs were determined and ranged in between 5.1 to 10.9 and 6.1 to 7.1. Results showed that remarkable increase in aqueous solubility of Fluconazole in presence of large concentration of hydrotropes. Marketed fluconazole tablets determined by spectrophotometric analysis using hydrotropic solubilization techniques. Validation of the proposed analysis methods  is  confirmed  by  satisfactorily  low  values  of  statistical  parameters  viz., standard deviation, percent coefficient of variation and standard error.

Keywords: Solubility enhancement, hydrotropes, Solid dispersion

Author Biography

Anu Kaushik*, Rakesh Kumar Jat

In the present research work mixed hydrotropic solubilization phenomenon is used to enhance the solubilization of poorly water soluble drugs. Bulk drug samples were identified by the observed IR spectra and the melting points determination. Sodium benzoate, niacinamide and urea are the hydrotropes were selected for the solubility enhancement of drugs Solubility enhancement ratios for selected poorly water-soluble drugs were determined and ranged in between 5.1 to 10.9 and 6.1 to 7.1. Results showed that remarkable increase in aqueous solubility of Fluconazole in presence of large concentration of hydrotropes. Marketed fluconazole tablets determined by spectrophotometric analysis using hydrotropic solubilization techniques. Validation of the proposed analysis methods  is  confirmed  by  satisfactorily  low  values  of  statistical  parameters  viz., standard deviation, percent coefficient of variation and standard error.

Keywords: Solubility enhancement, hydrotropes, Solid dispersion

Published
2017-06-30
How to Cite
Jat, A. K. R. K. (2017). SOLUBLITY ENHANCEMENT OF FLUCONAZOLE BY FORMULATION OF HYDROTROPIC SOLID DISPERSIONS. Journal of Biomedical and Pharmaceutical Research, 6(3). Retrieved from http://jbpr.in/index.php/jbpr/article/view/54
Issue
Vol. 6 No. 3 (2017)
Section
Research Articles

Creative Commons LicenseJournal of Biomedical and Pharmaceutical Research by Articles is licensed under a Creative Commons Attribution 4.0 International License.