FUNCTIONAL ROLES OF LIPID METABOLITE CDP DIACYLGLYCEROL AND ITS SYNTHASE ENZYMES: RECENT DEVELOPMENTS

  • Manoj G Tyagi NIMS College of Paramedical Technology, NIMS University, Jaipur, Rajasthan
  • Dharmendra Singh NIMS College of Paramedical Technology, NIMS University, Jaipur, Rajasthan
  • Nirmala Joyce Department of Chemical Engineering, IIT Chennai*, Tamilnadu
  • Mohammed Amil NIMS College of Paramedical Technology, NIMS University, Jaipur, Rajasthan
  • Shyam S Yadav NIMS College of Paramedical Technology, NIMS University, Jaipur, Rajasthan
DOI: https://doi.org/10.32553/jbpr.v8i1.572

Abstract

Phospholipids are basic building-block molecules for biological membranes. Biosynthesis of phospholipids i.e phosphatidylinositol, phosphatidylglycerol and phosphatidylserine requires a central liponucleotide intermediate named cytidine-diphosphate diacylglycerol (CDP-DAG). The CDP-DAG synthase (CDS) is an integral membrane enzyme catalysing the formation of CDP-DAG, an essential step for phosphoinositide recycling during signal transduction. New roles are being ascribed to the CDP-DAG in signalling and pathophysiological conditions. This pathway may also be the target of novel drugs to be used in neuro-psychiatric conditions.

Key words: Phospholipids, Cytidine diphosphate, diacylglycerol, phosphatidic acid, phosphatidylglycerol.

Published
2019-02-26
How to Cite
Tyagi, M. G., Singh, D., Joyce, N., Amil, M., & Yadav, S. S. (2019). FUNCTIONAL ROLES OF LIPID METABOLITE CDP DIACYLGLYCEROL AND ITS SYNTHASE ENZYMES: RECENT DEVELOPMENTS. Journal of Biomedical and Pharmaceutical Research, 8(1), 38-43. https://doi.org/10.32553/jbpr.v8i1.572
Issue
Vol. 8 No. 1 (2019)
Section
Research Articles

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