FORMULATION AND EVALUATION OF NASAL IN SITU GEL OF RIZATRIPTAN BENZOATE

Abstract

In situ gel drug delivery systems are in elucidation form prior to supervision but once administered, endure gelation in situ, to form a gel. In the current revise nasal in situ gel of rizatriptan Benzoate was primed for the cure of nasal infections to give sustained release of drug and to attain site specific action. Carbopol was use as a pH triggered polymer Different formulations were prepared by varying the concentrations of Carbopo with Hydroxylpropyl Methylcellulose (HPMC). These formulations were evaluated for parameters like drug excipient compatibility, pH, drug content, gelation temperature, viscosity, in vitro drug release, mucoadhesion, ex vivo permeation and stability studies. FTIR study exposed that there was no interface between drug and polymer. pH of all the formulations were initiate to be in the vary of 5.4-6.2 and the drug substance for all the prepared formulations was initiate to be in the assortment of 94%-99%. The results of in vitro drug release and mucoadhesive strength indicated that the optimized formulation F5 and is the most successful formulations of the study, exhibited a sustained drug release of in 87.7% in 7 hours. mucoadhesive strength of 2024.64 and 3267.76 dyne/cm2. From the results it is fulfilled that rizatriptan Benzoate nasal in situ gel produce extended and site specific drug delivery.

Keywords: Nasal drug delivery, Rizatriptan Benzoate, In Situ nasal gel, Mucoadhesion.