A REVIEW ARTICLE ON: CORONA VIRUS A RAISING GAINT

Abstract

The 2019-nCoV has been identified as the reason of an outbreak of respiratory illness in Wuhan, Hubei Province, China beginning in December 2019. This outbreak had spread to 19 countries with 11,791 confirmed cases, including 213 deaths, as of January 31, 2020. The WHO declared it as a Public Health Emergency of International Concern. This study analyzed and discussed 70 research articles published until January 31, 2020 for a better understanding of the virology, pathogenesis, mode of transmission, classification, genome structure of this virus. Studies thus far have shown origination in link to a seafood market in Wuhan, but specific animal association has not been confirmed. The reported symptoms include fever, cough, fatigue, pneumonia, headache, diarrhea, hemoptysis, and dyspnea. Preventive measures like masks, hand hygiene practices, avoidance of public contact, case detection, contact tracing, and quarantines are being suggested for reducing the transmission. To date, no specific antiviral treatment is proven effective; hence, infected people primarily rely on symptomatic treatment and supportive care. Although these studies had relevance to control a public emergency, more research need to be conducted to provide valid and reliable ways to manage this kind of public health emergency in both short- and long- term. Coronaviruses (CoV) belong to the genus Coronavirus with its high mutation rate in the Corona viridae. The objective of this review article was to have a primary   opinion about the disease mode of transmission, virology in this early stage of COVID-19 outbreak.

Keywords: 2019-nCoV, virology, pathogenesis, genome structure