PROSPECTIVE ANALYSIS OF IMPACT OF PHARMCOTHERAPY ADHERENCE ON TREATMENT EFFECTIVENESS IN POST OPERATIVE HEART PATIENTS

Samridhi  Khandelwal; Vandana  Sharma; Ramesh  Pareek; Shailendra  Tripathi; Shankar  Soni; Pawan  Upadhyay

doi:10.32553/jbpr.v10i1.836

Samridhi Khandelwal Research Scholar, Arya College of Pharmacy, Jaipur
Vandana Sharma Professor, Arya College of Pharmacy, Jaipur
Ramesh Pareek Asso. Professor, Arya College of pharmacy, Jaipur
Shailendra Tripathi Asso. Professor, Arya College of pharmacy, Jaipur
Shankar Soni Asso. Professor, Arya College of pharmacy, Jaipur
Pawan Upadhyay Research Scholar, Arya College of Pharmacy, Jaipur

DOI: https://doi.org/10.32553/jbpr.v10i1.836

Abstract

Myocardial infarction is the irreversible damage of myocardial tissue caused by prolonged ischemia and hypoxia. This most commonly occurs when a coronary artery becomese blocked following the rupture of an atherosclerotic plaque, which then leads to the formation of a blood clot (coronary thrombosis). This event can also trigger coronary vasospasm. Ischemia induces profound metabolic and ionic perturbations in the affected myocardium and causes rapid depression of systolic function. Prolonged myocardial ischemia activates a "wavefront" of cardiomyocyte death that extends from the subendocardium to the subepicardium. Mitochondrial alterations are prominently involved in apoptosis and necrosis of cardiomyocytes in the infarcted heart.

This prospective, pilot, observational study performed confirmed the hypothesis that systematic identifications and interventions administered through continued physician follow-up and patients counselling will improve adherence to therapy and therefore improvement in treatment effectiveness by lowering especially Troponin level ,CPK and quality of life in MI patients.

Study was shown that lack of proper knowledge about disease and patients counseling and chronic treatment, most of patients takes disease and its treatment lightly and shows lower adherence attitude. The study analysis shown that female are generally more aware than males for adherence. Study analysis concluded that there was significant reduction in their Troponin level and CPK values in different comparison groups after each level of follow up.

Statistical analysis concluded that patients with adherence ˃ 95% showed significant reduction in Troponin level and CPK values and patients with age group ≤50 shows more adherence than older.

Most heart patients recorded with hypertension and Coronary Artery Diseases only few ones with diabetic complications. During study patients shows good control over their blood pressure and only few adverse events but no complications occur during study period.